Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase
Key points Sensitivity analysis confirmed optimization conditions for ATPS L-ASNase recovery Fed-batch fermentation outperformed other modes in techno-economic evaluations Fusant improved clinical and industrial characteristics indicate recombination success
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-01-01
|
| Series: | AMB Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13568-022-01505-8 |
| _version_ | 1828069419479203840 |
|---|---|
| author | Atim Asitok Maurice Ekpenyong Andrew Amenaghawon Ernest Akwagiobe Marcus Asuquo Anitha Rao David Ubi Juliet Iheanacho Joyce Etiosa Agnes Antai Joseph Essien Sylvester Antai |
| author_facet | Atim Asitok Maurice Ekpenyong Andrew Amenaghawon Ernest Akwagiobe Marcus Asuquo Anitha Rao David Ubi Juliet Iheanacho Joyce Etiosa Agnes Antai Joseph Essien Sylvester Antai |
| author_sort | Atim Asitok |
| collection | DOAJ |
| description | Key points Sensitivity analysis confirmed optimization conditions for ATPS L-ASNase recovery Fed-batch fermentation outperformed other modes in techno-economic evaluations Fusant improved clinical and industrial characteristics indicate recombination success |
| first_indexed | 2024-04-11T00:19:49Z |
| format | Article |
| id | doaj.art-844f2f051b8c4929b860c4d16b7a618c |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-04-11T00:19:49Z |
| publishDate | 2023-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-844f2f051b8c4929b860c4d16b7a618c2023-01-08T12:21:33ZengSpringerOpenAMB Express2191-08552023-01-0113111810.1186/s13568-022-01505-8Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginaseAtim Asitok0Maurice Ekpenyong1Andrew Amenaghawon2Ernest Akwagiobe3Marcus Asuquo4Anitha Rao5David Ubi6Juliet Iheanacho7Joyce Etiosa8Agnes Antai9Joseph Essien10Sylvester Antai11Environmental Microbiology and Biotechnology Unit, Department of Microbiology, University of CalabarEnvironmental Microbiology and Biotechnology Unit, Department of Microbiology, University of CalabarDepartment of Chemical Engineering, University of BeninIndustrial Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of CalabarDepartment of Hematology, University of Calabar Teaching HospitalIndustrial Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of CalabarIndustrial Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of CalabarEnvironmental Microbiology and Biotechnology Unit, Department of Microbiology, University of CalabarEnvironmental Microbiology and Biotechnology Unit, Department of Microbiology, University of CalabarDepartment of Economics, Faculty of Social Sciences, University of CalabarDepartment of Microbiology, Faculty of Science, University of UyoEnvironmental Microbiology and Biotechnology Unit, Department of Microbiology, University of CalabarKey points Sensitivity analysis confirmed optimization conditions for ATPS L-ASNase recovery Fed-batch fermentation outperformed other modes in techno-economic evaluations Fusant improved clinical and industrial characteristics indicate recombination successhttps://doi.org/10.1186/s13568-022-01505-8Protoplast fusionl-ASNaseSensitivity analysisAnti-leukemic activityAcrylamide mitigationTechno-economics |
| spellingShingle | Atim Asitok Maurice Ekpenyong Andrew Amenaghawon Ernest Akwagiobe Marcus Asuquo Anitha Rao David Ubi Juliet Iheanacho Joyce Etiosa Agnes Antai Joseph Essien Sylvester Antai Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase AMB Express Protoplast fusion l-ASNase Sensitivity analysis Anti-leukemic activity Acrylamide mitigation Techno-economics |
| title | Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase |
| title_full | Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase |
| title_fullStr | Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase |
| title_full_unstemmed | Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase |
| title_short | Production, characterization and techno-economic evaluation of Aspergillus fusant l-asparaginase |
| title_sort | production characterization and techno economic evaluation of aspergillus fusant l asparaginase |
| topic | Protoplast fusion l-ASNase Sensitivity analysis Anti-leukemic activity Acrylamide mitigation Techno-economics |
| url | https://doi.org/10.1186/s13568-022-01505-8 |
| work_keys_str_mv | AT atimasitok productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT mauriceekpenyong productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT andrewamenaghawon productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT ernestakwagiobe productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT marcusasuquo productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT anitharao productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT davidubi productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT julietiheanacho productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT joyceetiosa productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT agnesantai productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT josephessien productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase AT sylvesterantai productioncharacterizationandtechnoeconomicevaluationofaspergillusfusantlasparaginase |