Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension
Purpose: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffn...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-07-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2018.1476055 |
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| author | Radovan Prijić Vedran Premužić Marko Brinar Željko Krznarić Bojan Jelaković Silvija Čuković-Čavka |
| author_facet | Radovan Prijić Vedran Premužić Marko Brinar Željko Krznarić Bojan Jelaković Silvija Čuković-Čavka |
| author_sort | Radovan Prijić |
| collection | DOAJ |
| description | Purpose: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. Materials and methods: A total of 89 inflammatory bowel disease patients (60 patients with Crohn’s disease and 29 patients with ulcerative colitis, age range 20–64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25–69 years, 41 (56.1%) males) with known history of well-controlled arterial hypertension. We have used a noninvasive device that simultaneously measures brachial blood pressure and estimates PWV and AIx in inflammatory bowel disease and hypertension groups of patients. Results: Patients with pathological PWV values were significantly older, had significantly longer duration of inflammatory bowel disease, higher values of serum cholesterol and HDL-cholesterol, and higher AIx (17.4% vs. 9.8%) (all p < .05). Higher PWV was associated with age and duration of inflammatory bowel disease in the linear regression model. PWV values were higher in hypertensive patients in the first two age quartiles while interestingly, in the last two quartiles, PWV was lower than in inflammatory bowel disease group of patients. Conclusions: Chronic subclinical inflammation is responsible for dyslipidemia and accelerated atherosclerosis which consequently alterates arterial elasticity. Inflammatory bowel disease and its duration should also be considered a risk factor for subclinical organ damage, as well as hypertension. |
| first_indexed | 2024-03-12T00:39:14Z |
| format | Article |
| id | doaj.art-8453d8fbe4314f5081e16be11ce176de |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:14Z |
| publishDate | 2018-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-8453d8fbe4314f5081e16be11ce176de2023-09-15T08:45:22ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992018-07-0127424024610.1080/08037051.2018.14760551476055Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertensionRadovan Prijić0Vedran Premužić1Marko Brinar2Željko Krznarić3Bojan Jelaković4Silvija Čuković-Čavka5University Hospital Centre ZagrebUniversity Hospital Centre Zagreb, University of Zagreb School of MedicineUniversity Hospital Centre Zagreb, University of Zagreb School of MedicineUniversity Hospital Centre Zagreb, University of Zagreb School of MedicineUniversity Hospital Centre Zagreb, University of Zagreb School of MedicineUniversity Hospital Centre Zagreb, University of Zagreb School of MedicinePurpose: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. Materials and methods: A total of 89 inflammatory bowel disease patients (60 patients with Crohn’s disease and 29 patients with ulcerative colitis, age range 20–64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25–69 years, 41 (56.1%) males) with known history of well-controlled arterial hypertension. We have used a noninvasive device that simultaneously measures brachial blood pressure and estimates PWV and AIx in inflammatory bowel disease and hypertension groups of patients. Results: Patients with pathological PWV values were significantly older, had significantly longer duration of inflammatory bowel disease, higher values of serum cholesterol and HDL-cholesterol, and higher AIx (17.4% vs. 9.8%) (all p < .05). Higher PWV was associated with age and duration of inflammatory bowel disease in the linear regression model. PWV values were higher in hypertensive patients in the first two age quartiles while interestingly, in the last two quartiles, PWV was lower than in inflammatory bowel disease group of patients. Conclusions: Chronic subclinical inflammation is responsible for dyslipidemia and accelerated atherosclerosis which consequently alterates arterial elasticity. Inflammatory bowel disease and its duration should also be considered a risk factor for subclinical organ damage, as well as hypertension.http://dx.doi.org/10.1080/08037051.2018.1476055inflammatory bowel diseasearterial stiffnessarterial hypertensionvascular agingchronic inflammationpulse wave velocity |
| spellingShingle | Radovan Prijić Vedran Premužić Marko Brinar Željko Krznarić Bojan Jelaković Silvija Čuković-Čavka Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension Blood Pressure inflammatory bowel disease arterial stiffness arterial hypertension vascular aging chronic inflammation pulse wave velocity |
| title | Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension |
| title_full | Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension |
| title_fullStr | Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension |
| title_full_unstemmed | Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension |
| title_short | Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension |
| title_sort | increased arterial stiffness similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well controlled hypertension |
| topic | inflammatory bowel disease arterial stiffness arterial hypertension vascular aging chronic inflammation pulse wave velocity |
| url | http://dx.doi.org/10.1080/08037051.2018.1476055 |
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