Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy
ObjectiveTo evaluate the use of rectal mucosal cleansings before transrectal ultrasound-guided prostate biopsy with a transrectal approach, comparing the safety profile of chlorhexidine and povidone-iodine.MethodsWe conducted a retrospective analysis of our prospectively maintained database between...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Urology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fruro.2023.1176965/full |
| _version_ | 1797792303190900736 |
|---|---|
| author | Adriana M. Pedraza Adriana M. Pedraza Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga María Alejandra Zapata Copete María Alejandra Zapata Copete Dhruti Patel Herney Andrés García-Perdomo Herney Andrés García-Perdomo |
| author_facet | Adriana M. Pedraza Adriana M. Pedraza Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga María Alejandra Zapata Copete María Alejandra Zapata Copete Dhruti Patel Herney Andrés García-Perdomo Herney Andrés García-Perdomo |
| author_sort | Adriana M. Pedraza |
| collection | DOAJ |
| description | ObjectiveTo evaluate the use of rectal mucosal cleansings before transrectal ultrasound-guided prostate biopsy with a transrectal approach, comparing the safety profile of chlorhexidine and povidone-iodine.MethodsWe conducted a retrospective analysis of our prospectively maintained database between August 2019 to September 2020 in a high-volume hospital in Cali, Colombia. 428 consecutive patients who underwent TRUS-PB with a transrectal approach were included in this study. 117 patients received povidone-iodine and 311 patients received chlorhexidine for rectal mucosa cleansings. After the procedure, we conducted telephone follow-ups at 48 hours, 7 days, and 30 days. The complications were registered in our database. Analysis was performed using STATA 15.ResultsThere was a statistically significant increased risk of hematuria, urinary retention, and rectal bleeding in those patients exposed to Chlorhexidine (p <0.001, <0.001, and 0.01 respectively). We did not find any differences in sepsis (p 0.18) or urinary tract infection (p 0.77) rates between the groups. Rectal antisepsis with chlorhexidine significantly increased the risk of non-infectious complications.ConclusionsIn terms of infectious complications, there were no differences between the use of povidone-iodine and chlorhexidine for rectal mucosal cleansing prior to TRUS-PB. Povidone iodine appeared to be a safer option, as it is associated with fewer risks of hematuria, rectal bleeding, and urine retention. |
| first_indexed | 2024-03-13T02:31:13Z |
| format | Article |
| id | doaj.art-845605003ec149db8e54f3d4b8258ecd |
| institution | Directory Open Access Journal |
| issn | 2673-9828 |
| language | English |
| last_indexed | 2024-03-13T02:31:13Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Urology |
| spelling | doaj.art-845605003ec149db8e54f3d4b8258ecd2023-06-29T14:14:02ZengFrontiers Media S.A.Frontiers in Urology2673-98282023-06-01310.3389/fruro.2023.11769651176965Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsyAdriana M. Pedraza0Adriana M. Pedraza1Jeffer David Álvarez Villarraga2Jeffer David Álvarez Villarraga3Jeffer David Álvarez Villarraga4Jeffer David Álvarez Villarraga5María Alejandra Zapata Copete6María Alejandra Zapata Copete7Dhruti Patel8Herney Andrés García-Perdomo9Herney Andrés García-Perdomo10Desa, Rafael Uribe Uribe Clinic, Cali, ColombiaIcahn School of Medicine at Mount Sinai, New York, NY, United StatesDesa, Rafael Uribe Uribe Clinic, Cali, ColombiaDepartment of Urology, Universidad Libre, Cali, ColombiaUROGIV Investigation Group, Universidad del Valle, Cali, ColombiaICESI University, Cali, ColombiaUROGIV Investigation Group, Universidad del Valle, Cali, ColombiaSchool of Medicine Pontificia Universidad Javeriana, Cali, ColombiaIcahn School of Medicine at Mount Sinai, New York, NY, United StatesUROGIV Investigation Group, Universidad del Valle, Cali, ColombiaDivision of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, ColombiaObjectiveTo evaluate the use of rectal mucosal cleansings before transrectal ultrasound-guided prostate biopsy with a transrectal approach, comparing the safety profile of chlorhexidine and povidone-iodine.MethodsWe conducted a retrospective analysis of our prospectively maintained database between August 2019 to September 2020 in a high-volume hospital in Cali, Colombia. 428 consecutive patients who underwent TRUS-PB with a transrectal approach were included in this study. 117 patients received povidone-iodine and 311 patients received chlorhexidine for rectal mucosa cleansings. After the procedure, we conducted telephone follow-ups at 48 hours, 7 days, and 30 days. The complications were registered in our database. Analysis was performed using STATA 15.ResultsThere was a statistically significant increased risk of hematuria, urinary retention, and rectal bleeding in those patients exposed to Chlorhexidine (p <0.001, <0.001, and 0.01 respectively). We did not find any differences in sepsis (p 0.18) or urinary tract infection (p 0.77) rates between the groups. Rectal antisepsis with chlorhexidine significantly increased the risk of non-infectious complications.ConclusionsIn terms of infectious complications, there were no differences between the use of povidone-iodine and chlorhexidine for rectal mucosal cleansing prior to TRUS-PB. Povidone iodine appeared to be a safer option, as it is associated with fewer risks of hematuria, rectal bleeding, and urine retention.https://www.frontiersin.org/articles/10.3389/fruro.2023.1176965/fullprostate biopsyiodine povidonechlorhexidinerectal antisepsistransrectal ultrasound |
| spellingShingle | Adriana M. Pedraza Adriana M. Pedraza Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga Jeffer David Álvarez Villarraga María Alejandra Zapata Copete María Alejandra Zapata Copete Dhruti Patel Herney Andrés García-Perdomo Herney Andrés García-Perdomo Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy Frontiers in Urology prostate biopsy iodine povidone chlorhexidine rectal antisepsis transrectal ultrasound |
| title | Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy |
| title_full | Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy |
| title_fullStr | Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy |
| title_full_unstemmed | Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy |
| title_short | Safety profile of chlorhexidine and povidone-iodine in rectal mucosa cleansing during prostate biopsy |
| title_sort | safety profile of chlorhexidine and povidone iodine in rectal mucosa cleansing during prostate biopsy |
| topic | prostate biopsy iodine povidone chlorhexidine rectal antisepsis transrectal ultrasound |
| url | https://www.frontiersin.org/articles/10.3389/fruro.2023.1176965/full |
| work_keys_str_mv | AT adrianampedraza safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT adrianampedraza safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT jefferdavidalvarezvillarraga safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT jefferdavidalvarezvillarraga safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT jefferdavidalvarezvillarraga safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT jefferdavidalvarezvillarraga safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT mariaalejandrazapatacopete safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT mariaalejandrazapatacopete safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT dhrutipatel safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT herneyandresgarciaperdomo safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy AT herneyandresgarciaperdomo safetyprofileofchlorhexidineandpovidoneiodineinrectalmucosacleansingduringprostatebiopsy |