Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers
OBJECTIVES: The eradication of Helicobacter (H.) pylori allows peptic ulcers in patients infected with the bacteria to be cured. Treatment with the classic triple regimen (proton pump inhibitor, amoxicillin and clarithromycin) has shown decreased efficacy due to increased bacterial resistance to cla...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2015-05-01
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000500318&lng=en&tlng=en |
| _version_ | 1818119322710573056 |
|---|---|
| author | Fernando Marcuz Silva Elaine Cristina Silveira de Queiroz Tomás Navarro-Rodriguez Ricardo Correa Barbuti Rejane Mattar Kiyoshi Iriya Jin Hwa Lee Jaime Natan Eisig |
| author_facet | Fernando Marcuz Silva Elaine Cristina Silveira de Queiroz Tomás Navarro-Rodriguez Ricardo Correa Barbuti Rejane Mattar Kiyoshi Iriya Jin Hwa Lee Jaime Natan Eisig |
| author_sort | Fernando Marcuz Silva |
| collection | DOAJ |
| description | OBJECTIVES: The eradication of Helicobacter (H.) pylori allows peptic ulcers in patients infected with the bacteria to be cured. Treatment with the classic triple regimen (proton pump inhibitor, amoxicillin and clarithromycin) has shown decreased efficacy due to increased bacterial resistance to clarithromycin. In our country, the eradication rate by intention to treat with this regimen is 83%. In Brazil, a commercially available regimen for bacterial eradication that uses levofloxacin and amoxicillin with lansoprazole is available; however, its efficacy is not known. Considering that such a treatment may be an alternative to the classic regimen, we aimed to verify its efficacy in H. pylori eradication. METHODS: Patients with peptic ulcer disease infected with H. pylori who had not received prior treatment were treated with the following regimen: 30 mg lansoprazole bid, 1,000 mg amoxicillin bid and 500 mg levofloxacin, once a day for 7 days. RESULTS: A total of 66 patients were evaluated. The patients’ mean age was 52 years, and women comprised 55% of the sample. Duodenal ulcers were present in 50% of cases, and gastric ulcers were present in 30%. The eradication rate was 74% per protocol and 73% by intention to treat. Adverse effects were reported by 49 patients (74%) and were mild to moderate, with a prevalence of diarrhea complaints. CONCLUSIONS: Triple therapy comprising lansoprazole, amoxicillin and levofloxacin for 7 days for the eradication of H. pylori in Brazilian peptic ulcer patients showed a lower efficacy than that of the classic triple regimen. |
| first_indexed | 2024-12-11T05:08:22Z |
| format | Article |
| id | doaj.art-8456ba9a3dfe4faa825cb859ceb2af16 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T05:08:22Z |
| publishDate | 2015-05-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-8456ba9a3dfe4faa825cb859ceb2af162022-12-22T01:19:58ZengElsevier EspañaClinics1980-53222015-05-0170531832110.6061/clinics/2015(05)02S1807-59322015000500318Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcersFernando Marcuz SilvaElaine Cristina Silveira de QueirozTomás Navarro-RodriguezRicardo Correa BarbutiRejane MattarKiyoshi IriyaJin Hwa LeeJaime Natan EisigOBJECTIVES: The eradication of Helicobacter (H.) pylori allows peptic ulcers in patients infected with the bacteria to be cured. Treatment with the classic triple regimen (proton pump inhibitor, amoxicillin and clarithromycin) has shown decreased efficacy due to increased bacterial resistance to clarithromycin. In our country, the eradication rate by intention to treat with this regimen is 83%. In Brazil, a commercially available regimen for bacterial eradication that uses levofloxacin and amoxicillin with lansoprazole is available; however, its efficacy is not known. Considering that such a treatment may be an alternative to the classic regimen, we aimed to verify its efficacy in H. pylori eradication. METHODS: Patients with peptic ulcer disease infected with H. pylori who had not received prior treatment were treated with the following regimen: 30 mg lansoprazole bid, 1,000 mg amoxicillin bid and 500 mg levofloxacin, once a day for 7 days. RESULTS: A total of 66 patients were evaluated. The patients’ mean age was 52 years, and women comprised 55% of the sample. Duodenal ulcers were present in 50% of cases, and gastric ulcers were present in 30%. The eradication rate was 74% per protocol and 73% by intention to treat. Adverse effects were reported by 49 patients (74%) and were mild to moderate, with a prevalence of diarrhea complaints. CONCLUSIONS: Triple therapy comprising lansoprazole, amoxicillin and levofloxacin for 7 days for the eradication of H. pylori in Brazilian peptic ulcer patients showed a lower efficacy than that of the classic triple regimen.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000500318&lng=en&tlng=enPeptic ulcer therapyHelicobacter pylori drug effectslevofloxacinamoxicillin therapeutic use and adverse effects |
| spellingShingle | Fernando Marcuz Silva Elaine Cristina Silveira de Queiroz Tomás Navarro-Rodriguez Ricardo Correa Barbuti Rejane Mattar Kiyoshi Iriya Jin Hwa Lee Jaime Natan Eisig Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers Clinics Peptic ulcer therapy Helicobacter pylori drug effects levofloxacin amoxicillin therapeutic use and adverse effects |
| title | Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers |
| title_full | Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers |
| title_fullStr | Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers |
| title_full_unstemmed | Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers |
| title_short | Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers |
| title_sort | efficacy of levofloxacin amoxicillin and a proton pump inhibitor in the eradication of helicobacter pylori in brazilian patients with peptic ulcers |
| topic | Peptic ulcer therapy Helicobacter pylori drug effects levofloxacin amoxicillin therapeutic use and adverse effects |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000500318&lng=en&tlng=en |
| work_keys_str_mv | AT fernandomarcuzsilva efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT elainecristinasilveiradequeiroz efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT tomasnavarrorodriguez efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT ricardocorreabarbuti efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT rejanemattar efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT kiyoshiiriya efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT jinhwalee efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers AT jaimenataneisig efficacyoflevofloxacinamoxicillinandaprotonpumpinhibitorintheeradicationofhelicobacterpyloriinbrazilianpatientswithpepticulcers |