Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Abstract Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against the neurotoxic effects of cisplatin tre...

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Bibliographic Details
Main Authors: Nabila Boukelmoune, Gabriel S. Chiu, Annemieke Kavelaars, Cobi J. Heijnen
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Acta Neuropathologica Communications
Subjects:
Mesenchymal stem cells
Neuronal stem cells
Mitochondrial transfer
Cisplatin
Online Access:http://link.springer.com/article/10.1186/s40478-018-0644-8

Internet

http://link.springer.com/article/10.1186/s40478-018-0644-8

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