Application of traditional Chinese medicine as skin depigmentation agents
Traditional Chinese medicine (TCM) has been frequently used as skin lightning agents. However, the mechanism of action of their effect is unclear. The present study aims to evaluate anti-tyrosinase activity of 10 commonly used TCM on mushroom (ab), human (hs) and mouse melanoma B16F0 (mm) tyrosinase...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022038592 |
| _version_ | 1797960821140094976 |
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| author | Tina Liu Yaoying Lu Kathryn Tonissen Giovanna Di Trapani William Tang Yunjiang Feng |
| author_facet | Tina Liu Yaoying Lu Kathryn Tonissen Giovanna Di Trapani William Tang Yunjiang Feng |
| author_sort | Tina Liu |
| collection | DOAJ |
| description | Traditional Chinese medicine (TCM) has been frequently used as skin lightning agents. However, the mechanism of action of their effect is unclear. The present study aims to evaluate anti-tyrosinase activity of 10 commonly used TCM on mushroom (ab), human (hs) and mouse melanoma B16F0 (mm) tyrosinase (TYR) respectively. The results showed that at 1.0 mg/mL, extracts from Rosa rugosa Thumb, Morus alba L. and Paeonia lactiflora Pall were active against both abTYR and hsTYR (>50% inhibition), extracts from Bletilla striata (Thunb.) Rchb. F., Centella asiatica (L.) Urb, Cynanchum atratum L., Rosa canina L., Rhus chinensis Mill. and Glycyrrhiza urolensis Fisch. Ex DC. inhibited either abTYR or hsTYR (>50%), while extract from Tribulus terrestris L. had no/minimal activity (<10% inhibition). When treated with melanoma B16F0 cells, M. alba also significantly reduced mmTYR activity (70% at 250 μg/mL) and melanin content (50% at 250 μg/mL). These findings demonstrated inhibitory effects of 9 TCM against TYR and hence support their application as skin lightning agents. Our results also showed discrepancies in TYR activity from different sources, suggesting a testing regime of combining abTYR, hsTYR and mmTYR when developing depigmentation agents for human application. |
| first_indexed | 2024-04-11T00:50:12Z |
| format | Article |
| id | doaj.art-845af4964df84dbca7372ce30f49533e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T00:50:12Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-845af4964df84dbca7372ce30f49533e2023-01-05T08:41:00ZengElsevierHeliyon2405-84402022-12-01812e12571Application of traditional Chinese medicine as skin depigmentation agentsTina Liu0Yaoying Lu1Kathryn Tonissen2Giovanna Di Trapani3William Tang4Yunjiang Feng5Griffith Institute for Drug Discovery, 46 Don Young Rd, Nathan, QLD 4111, Brisbane, AustraliaGriffith Institute for Drug Discovery, 46 Don Young Rd, Nathan, QLD 4111, Brisbane, Australia; School of Environment and Science, 170 Kessels Rd, Nathan, QLD 4111, Brisbane, AustraliaGriffith Institute for Drug Discovery, 46 Don Young Rd, Nathan, QLD 4111, Brisbane, Australia; School of Environment and Science, 170 Kessels Rd, Nathan, QLD 4111, Brisbane, AustraliaSchool of Environment and Science, 170 Kessels Rd, Nathan, QLD 4111, Brisbane, AustraliaFerngrove Pharmaceutical Pty Ltd, 5 Ferngrove Pl, Chester Hill, NSW 2162, Sydney, AustraliaGriffith Institute for Drug Discovery, 46 Don Young Rd, Nathan, QLD 4111, Brisbane, Australia; School of Environment and Science, 170 Kessels Rd, Nathan, QLD 4111, Brisbane, Australia; Corresponding author.Traditional Chinese medicine (TCM) has been frequently used as skin lightning agents. However, the mechanism of action of their effect is unclear. The present study aims to evaluate anti-tyrosinase activity of 10 commonly used TCM on mushroom (ab), human (hs) and mouse melanoma B16F0 (mm) tyrosinase (TYR) respectively. The results showed that at 1.0 mg/mL, extracts from Rosa rugosa Thumb, Morus alba L. and Paeonia lactiflora Pall were active against both abTYR and hsTYR (>50% inhibition), extracts from Bletilla striata (Thunb.) Rchb. F., Centella asiatica (L.) Urb, Cynanchum atratum L., Rosa canina L., Rhus chinensis Mill. and Glycyrrhiza urolensis Fisch. Ex DC. inhibited either abTYR or hsTYR (>50%), while extract from Tribulus terrestris L. had no/minimal activity (<10% inhibition). When treated with melanoma B16F0 cells, M. alba also significantly reduced mmTYR activity (70% at 250 μg/mL) and melanin content (50% at 250 μg/mL). These findings demonstrated inhibitory effects of 9 TCM against TYR and hence support their application as skin lightning agents. Our results also showed discrepancies in TYR activity from different sources, suggesting a testing regime of combining abTYR, hsTYR and mmTYR when developing depigmentation agents for human application.http://www.sciencedirect.com/science/article/pii/S2405844022038592Traditional Chinese medicine (TCM)TyrosinaseTyrosinase inhibitorSkin lightning |
| spellingShingle | Tina Liu Yaoying Lu Kathryn Tonissen Giovanna Di Trapani William Tang Yunjiang Feng Application of traditional Chinese medicine as skin depigmentation agents Heliyon Traditional Chinese medicine (TCM) Tyrosinase Tyrosinase inhibitor Skin lightning |
| title | Application of traditional Chinese medicine as skin depigmentation agents |
| title_full | Application of traditional Chinese medicine as skin depigmentation agents |
| title_fullStr | Application of traditional Chinese medicine as skin depigmentation agents |
| title_full_unstemmed | Application of traditional Chinese medicine as skin depigmentation agents |
| title_short | Application of traditional Chinese medicine as skin depigmentation agents |
| title_sort | application of traditional chinese medicine as skin depigmentation agents |
| topic | Traditional Chinese medicine (TCM) Tyrosinase Tyrosinase inhibitor Skin lightning |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022038592 |
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