Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

Preferential interactions of excipients with the antibody surface govern their effect on the stability of antibodies in solution. We probed the preferential interactions of proline, arginine.HCl (Arg.HCl), and NaCl with three therapeutically relevant IgG1 antibodies via experiment and simulation. Wi...

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Bibliographic Details
Main Authors: Theresa K. Cloutier, Chaitanya Sudrik, Neil Mody, Sathish A. Hasige, Bernhardt L. Trout
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Preferential interaction coefficients
proline
arginine.HCl
Nacl
mAbs
aggregation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1816312

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