Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis
ObjectiveTo systematically evaluate the effects of resistance training (RT) on muscle strength and muscle hypertrophy in elderly cancer patients, and to provide dose–response relationships of RT variables that could improve muscle strength and morphology in elderly cancer patients.MethodThe Review M...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1049248/full |
| _version_ | 1797851448036294656 |
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| author | Haiting Zhai Haiting Zhai Hongwen Wei Jixiang Xia Wei Wang |
| author_facet | Haiting Zhai Haiting Zhai Hongwen Wei Jixiang Xia Wei Wang |
| author_sort | Haiting Zhai |
| collection | DOAJ |
| description | ObjectiveTo systematically evaluate the effects of resistance training (RT) on muscle strength and muscle hypertrophy in elderly cancer patients, and to provide dose–response relationships of RT variables that could improve muscle strength and morphology in elderly cancer patients.MethodThe Review Manager 5.3 was applied to analyze the 12 literatures (616 participants) through random or fixed effects model and global effect size to examine upper limb strength, lower extremity strength, and muscle hypertrophy. Sub-group analysis was made on five variables: the total number of repeated training times/week, load intensity, exercise frequency/week, exercise duration and gender. This study also examines the heterogeneity and publication bias.ResultsTwelve literatures (616 participants, 60–80 years) were included in meta-analysis. RT significantly increased the upper limb muscular strength (SMD = 0.51, 95% CI: 0.10–0.93; Z = 2.41; p = 0.02) and lower extremity strength (SMD = 0.48, 95% CI: 0.28–0.67; Z = 4.82; p < 0.00001), but had no significant effect on muscle morphology(SMD = 0.21, 95% CI: 0.01–0.42; Z = 1.88; p = 0.06). In subgroup analysis for lower extremity muscle strength in elderly male cancer patients, it was found that male intensity of 70–90%1RM, volume of 400–500 times per week, frequencies of 3 times per week, and session of 12–24 weeks, revealed the greatest effect. Funnel plot of the three studies shows that the results were reliable, and no publication bias was found.ConclusionRT had medium effects on improving muscle strength in elderly cancer patients, but it is not effective in improving muscle hypertrophy. In addition, when RT is performed, different training protocols can have an effect on the growth of muscle strength. Therefore, a lower extremity training protocol with a training intensity of 70–90% 1RM, a total of 400–500 repetitions per week, 3 times per week, and an exercise session of 12–24 weeks is most effective in improving lower extremity strength in elderly male cancer patients. |
| first_indexed | 2024-04-09T19:16:55Z |
| format | Article |
| id | doaj.art-845ed44c95584ec18c13669d8fb2a5d8 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T19:16:55Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-845ed44c95584ec18c13669d8fb2a5d82023-04-06T04:39:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-04-011010.3389/fmed.2023.10492481049248Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysisHaiting Zhai0Haiting Zhai1Hongwen Wei2Jixiang Xia3Wei Wang4School of Basic Sciences for Aviation, Naval Aviation University, Yantai, ChinaSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, ChinaSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, ChinaSchool of Basic Sciences for Aviation, Naval Aviation University, Yantai, ChinaSchool of Basic Sciences for Aviation, Naval Aviation University, Yantai, ChinaObjectiveTo systematically evaluate the effects of resistance training (RT) on muscle strength and muscle hypertrophy in elderly cancer patients, and to provide dose–response relationships of RT variables that could improve muscle strength and morphology in elderly cancer patients.MethodThe Review Manager 5.3 was applied to analyze the 12 literatures (616 participants) through random or fixed effects model and global effect size to examine upper limb strength, lower extremity strength, and muscle hypertrophy. Sub-group analysis was made on five variables: the total number of repeated training times/week, load intensity, exercise frequency/week, exercise duration and gender. This study also examines the heterogeneity and publication bias.ResultsTwelve literatures (616 participants, 60–80 years) were included in meta-analysis. RT significantly increased the upper limb muscular strength (SMD = 0.51, 95% CI: 0.10–0.93; Z = 2.41; p = 0.02) and lower extremity strength (SMD = 0.48, 95% CI: 0.28–0.67; Z = 4.82; p < 0.00001), but had no significant effect on muscle morphology(SMD = 0.21, 95% CI: 0.01–0.42; Z = 1.88; p = 0.06). In subgroup analysis for lower extremity muscle strength in elderly male cancer patients, it was found that male intensity of 70–90%1RM, volume of 400–500 times per week, frequencies of 3 times per week, and session of 12–24 weeks, revealed the greatest effect. Funnel plot of the three studies shows that the results were reliable, and no publication bias was found.ConclusionRT had medium effects on improving muscle strength in elderly cancer patients, but it is not effective in improving muscle hypertrophy. In addition, when RT is performed, different training protocols can have an effect on the growth of muscle strength. Therefore, a lower extremity training protocol with a training intensity of 70–90% 1RM, a total of 400–500 repetitions per week, 3 times per week, and an exercise session of 12–24 weeks is most effective in improving lower extremity strength in elderly male cancer patients.https://www.frontiersin.org/articles/10.3389/fmed.2023.1049248/fullresistance trainingelderly cancer patientsupper limb strengthlower limb strengthmuscle morphologymeta-analysis |
| spellingShingle | Haiting Zhai Haiting Zhai Hongwen Wei Jixiang Xia Wei Wang Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis Frontiers in Medicine resistance training elderly cancer patients upper limb strength lower limb strength muscle morphology meta-analysis |
| title | Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis |
| title_full | Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis |
| title_fullStr | Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis |
| title_full_unstemmed | Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis |
| title_short | Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis |
| title_sort | dose response relationship of resistance training for muscle morphology and strength in elderly cancer patients a meta analysis |
| topic | resistance training elderly cancer patients upper limb strength lower limb strength muscle morphology meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1049248/full |
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