RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC
Objective: Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder that can be especially seen in children and young adults. The clinical presentation of patients with LCH varies according to the sites of involvement. In about half of patients, the disease is limited to a single organ sys...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137921012086 |
| _version_ | 1830301646292254720 |
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| author | Mehmet Can Ugur Sinem Namdaroglu Oktay Bilgir Cansu Atmaca Mutlu Füsun Gediz |
| author_facet | Mehmet Can Ugur Sinem Namdaroglu Oktay Bilgir Cansu Atmaca Mutlu Füsun Gediz |
| author_sort | Mehmet Can Ugur |
| collection | DOAJ |
| description | Objective: Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder that can be especially seen in children and young adults. The clinical presentation of patients with LCH varies according to the sites of involvement. In about half of patients, the disease is limited to a single organ system and bone involvement is very common. In this study, it was aimed to retrospectively evaluation the patients diagnosed with LCH who were followed up and treated in our clinic. Methodology: The data of patients over the age of 18 years who were followed up and treated in Bozyaka Training and Research Hospital Hematology Clinic between 2015-2021 were scanned retrospectively from the hospital system. Results: Data of 6 patients were obtained. The mean age of the patients was 33.6. There was no difference between the genders. Pain was the reason for admission in 4 patients and was the most common symptom. While the most frequently involved system was the skeletal system with 5 patients, lung involvement was seen in 2 patients. Vinblastine and prednisolone combination therapy was given to 1 patient, who developed steroid-related avascular necrosis. One patient who was planned for combination treatment Conclusion: LCH is a rare disease especially seen in children and young adults. It can involve the skeletal system, lungs, and other organs. The prognosis is often good with excision of the lesion or systemic treatment. |
| first_indexed | 2024-12-19T08:51:58Z |
| format | Article |
| id | doaj.art-846014ba5b5945e6a8bbf73315f12edd |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-12-19T08:51:58Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-846014ba5b5945e6a8bbf73315f12edd2022-12-21T20:28:41ZengElsevierHematology, Transfusion and Cell Therapy2531-13792021-11-0143S51S52RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINICMehmet Can Ugur0Sinem Namdaroglu1Oktay Bilgir2Cansu Atmaca Mutlu3Füsun Gediz4Health Sciences University, Bozyaka Training and Research Hospital, Department of HematologyHealth Sciences University, Bozyaka Training and Research Hospital, Department of HematologyHealth Sciences University, Bozyaka Training and Research Hospital, Department of HematologyIzmir Democrasy University, Buca Seyfi Demirsoy Training and Research Hospital, HematologyIzmir Economy University, Medicalpark Hospital, Deparment of HematologyObjective: Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder that can be especially seen in children and young adults. The clinical presentation of patients with LCH varies according to the sites of involvement. In about half of patients, the disease is limited to a single organ system and bone involvement is very common. In this study, it was aimed to retrospectively evaluation the patients diagnosed with LCH who were followed up and treated in our clinic. Methodology: The data of patients over the age of 18 years who were followed up and treated in Bozyaka Training and Research Hospital Hematology Clinic between 2015-2021 were scanned retrospectively from the hospital system. Results: Data of 6 patients were obtained. The mean age of the patients was 33.6. There was no difference between the genders. Pain was the reason for admission in 4 patients and was the most common symptom. While the most frequently involved system was the skeletal system with 5 patients, lung involvement was seen in 2 patients. Vinblastine and prednisolone combination therapy was given to 1 patient, who developed steroid-related avascular necrosis. One patient who was planned for combination treatment Conclusion: LCH is a rare disease especially seen in children and young adults. It can involve the skeletal system, lungs, and other organs. The prognosis is often good with excision of the lesion or systemic treatment.http://www.sciencedirect.com/science/article/pii/S2531137921012086 |
| spellingShingle | Mehmet Can Ugur Sinem Namdaroglu Oktay Bilgir Cansu Atmaca Mutlu Füsun Gediz RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC Hematology, Transfusion and Cell Therapy |
| title | RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC |
| title_full | RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC |
| title_fullStr | RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC |
| title_full_unstemmed | RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC |
| title_short | RETROSPECTIVE EVALUATION OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS FOLLOWED IN OUR CLINIC |
| title_sort | retrospective evaluation of patients with langerhans cell histiocytosis followed in our clinic |
| url | http://www.sciencedirect.com/science/article/pii/S2531137921012086 |
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