Carnitine and Sepsis: A Review of an Old Clinical Dilemma
Purpose. The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear. In this review, available experimental as well as clinical evidences regarding the probable beneficial effects of carnitine in sepsis were evaluated. Method. A comprehensive literature search was pe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-05-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/19207 |
| _version_ | 1797726797440221184 |
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| author | Shima Hatamkhani Iman Karimzadeh Sepideh Elyasi Shadi Farsaie Hossein Khalili |
| author_facet | Shima Hatamkhani Iman Karimzadeh Sepideh Elyasi Shadi Farsaie Hossein Khalili |
| author_sort | Shima Hatamkhani |
| collection | DOAJ |
| description | Purpose. The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear. In this review, available experimental as well as clinical evidences regarding the probable beneficial effects of carnitine in sepsis were evaluated. Method. A comprehensive literature search was performed in the related medical databases. Related experimental and clinical studies were included. Results and Conclusion: The plasma and tissue level of carnitine or its derivatives in septic condition is variable and inconclusive. Survival and outcomes are considered in only few studies. Despite its favorable safety profile, due to limited clinical evidence, it seems reasonable not to currently consider carnitine as a mandatory and beneficial supplement under septic conditions. Further well-designed, standard clinical trials are warranted in this regards.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page. |
| first_indexed | 2024-03-12T10:50:41Z |
| format | Article |
| id | doaj.art-846083ae84b54d89900ff2d438e0bf6a |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T10:50:41Z |
| publishDate | 2013-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-846083ae84b54d89900ff2d438e0bf6a2023-09-02T06:59:19ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262013-05-0116310.18433/J3JS4CCarnitine and Sepsis: A Review of an Old Clinical DilemmaShima Hatamkhani0Iman Karimzadeh1Sepideh Elyasi2Shadi Farsaie3Hossein Khalili4Tehran University of Medical Sciences, Tehran, IranTehran University of Medical Sciences, Tehran, IranTehran University of Medical Sciences, Tehran, IranTehran University of Medical Sciences, Tehran, IranTehran University of Medical Sciences, Tehran, IranPurpose. The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear. In this review, available experimental as well as clinical evidences regarding the probable beneficial effects of carnitine in sepsis were evaluated. Method. A comprehensive literature search was performed in the related medical databases. Related experimental and clinical studies were included. Results and Conclusion: The plasma and tissue level of carnitine or its derivatives in septic condition is variable and inconclusive. Survival and outcomes are considered in only few studies. Despite its favorable safety profile, due to limited clinical evidence, it seems reasonable not to currently consider carnitine as a mandatory and beneficial supplement under septic conditions. Further well-designed, standard clinical trials are warranted in this regards. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/19207 |
| spellingShingle | Shima Hatamkhani Iman Karimzadeh Sepideh Elyasi Shadi Farsaie Hossein Khalili Carnitine and Sepsis: A Review of an Old Clinical Dilemma Journal of Pharmacy & Pharmaceutical Sciences |
| title | Carnitine and Sepsis: A Review of an Old Clinical Dilemma |
| title_full | Carnitine and Sepsis: A Review of an Old Clinical Dilemma |
| title_fullStr | Carnitine and Sepsis: A Review of an Old Clinical Dilemma |
| title_full_unstemmed | Carnitine and Sepsis: A Review of an Old Clinical Dilemma |
| title_short | Carnitine and Sepsis: A Review of an Old Clinical Dilemma |
| title_sort | carnitine and sepsis a review of an old clinical dilemma |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/19207 |
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