Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.

The organismal roles of the ubiquitously expressed class I PI3K isoform p110β remain largely unknown. Using a new kinase-dead knockin mouse model that mimics constitutive pharmacological inactivation of p110β, we document that full inactivation of p110β leads to embryonic lethality in a substantial...

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Bibliographic Details
Main Authors: Julie Guillermet-Guibert, Lee B Smith, Guillaume Halet, Maria A Whitehead, Wayne Pearce, Diane Rebourcet, Kelly León, Pascale Crépieux, Gemma Nock, Maria Strömstedt, Malin Enerback, Claude Chelala, Mariona Graupera, John Carroll, Sabina Cosulich, Philippa T K Saunders, Ilpo Huhtaniemi, Bart Vanhaesebroeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4488938?pdf=render

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