HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design

HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design

VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens.

Bibliographic Details
Main Authors: Kim-Marie A. Dam, Christopher O. Barnes, Harry B. Gristick, Till Schoofs, Priyanthi N. P. Gnanapragasam, Michel C. Nussenzweig, Pamela J. Bjorkman
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33860-2
Description
Summary:VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens.
ISSN:2041-1723

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