HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design
VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33860-2 |
| _version_ | 1798028538224312320 |
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| author | Kim-Marie A. Dam Christopher O. Barnes Harry B. Gristick Till Schoofs Priyanthi N. P. Gnanapragasam Michel C. Nussenzweig Pamela J. Bjorkman |
| author_facet | Kim-Marie A. Dam Christopher O. Barnes Harry B. Gristick Till Schoofs Priyanthi N. P. Gnanapragasam Michel C. Nussenzweig Pamela J. Bjorkman |
| author_sort | Kim-Marie A. Dam |
| collection | DOAJ |
| description | VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens. |
| first_indexed | 2024-04-11T19:09:55Z |
| format | Article |
| id | doaj.art-84617c38677f4ed9a47137ef00a43a98 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:09:55Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-84617c38677f4ed9a47137ef00a43a982022-12-22T04:07:39ZengNature PortfolioNature Communications2041-17232022-10-0113111210.1038/s41467-022-33860-2HIV-1 CD4-binding site germline antibody–Env structures inform vaccine designKim-Marie A. Dam0Christopher O. Barnes1Harry B. Gristick2Till Schoofs3Priyanthi N. P. Gnanapragasam4Michel C. Nussenzweig5Pamela J. Bjorkman6Division of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyLaboratory of Molecular Immunology, The Rockefeller UniversityDivision of Biology and Biological Engineering, California Institute of TechnologyLaboratory of Molecular Immunology, The Rockefeller UniversityDivision of Biology and Biological Engineering, California Institute of TechnologyVRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens.https://doi.org/10.1038/s41467-022-33860-2 |
| spellingShingle | Kim-Marie A. Dam Christopher O. Barnes Harry B. Gristick Till Schoofs Priyanthi N. P. Gnanapragasam Michel C. Nussenzweig Pamela J. Bjorkman HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design Nature Communications |
| title | HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design |
| title_full | HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design |
| title_fullStr | HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design |
| title_full_unstemmed | HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design |
| title_short | HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design |
| title_sort | hiv 1 cd4 binding site germline antibody env structures inform vaccine design |
| url | https://doi.org/10.1038/s41467-022-33860-2 |
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