HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design
VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens.
Main Authors: | Kim-Marie A. Dam, Christopher O. Barnes, Harry B. Gristick, Till Schoofs, Priyanthi N. P. Gnanapragasam, Michel C. Nussenzweig, Pamela J. Bjorkman |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-33860-2 |
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