A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs
Pruritic dermatitis (PD) is a common presentation of canine allergic skin diseases, with diversity in severity and treatment response due to complex etiopathogenesis. Evidence suggests the gut microbiota (GM) may contribute to the development of canine allergies. A 10-week double-blind randomized co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/14/3/453 |
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| author | Devon E. Tate Jirayu Tanprasertsuk Roshonda B. Jones Heather Maughan Anirikh Chakrabarti Ehsan Khafipour Sharon A. Norton Justin Shmalberg Ryan W. Honaker |
| author_facet | Devon E. Tate Jirayu Tanprasertsuk Roshonda B. Jones Heather Maughan Anirikh Chakrabarti Ehsan Khafipour Sharon A. Norton Justin Shmalberg Ryan W. Honaker |
| author_sort | Devon E. Tate |
| collection | DOAJ |
| description | Pruritic dermatitis (PD) is a common presentation of canine allergic skin diseases, with diversity in severity and treatment response due to complex etiopathogenesis. Evidence suggests the gut microbiota (GM) may contribute to the development of canine allergies. A 10-week double-blind randomized controlled trial evaluated a novel probiotic and nutraceutical blend (PNB) on clinical signs of skin allergy, health measures, and the GM of privately owned self-reported pruritic dogs. A total of 105 dogs were enrolled, with 62 included in pruritus and health analysis and 50 in microbiome analysis. The PNB supported greater improvement of owner-assessed clinical signs of PD at week 2 than the placebo (PBO). More dogs that received the PNB shifted to normal pruritus (digital PVAS10-N: <2) by week 4, compared to week 7 for the PBO. While a placebo effect was identified, clinical differences were supported by changes in the GM. The PNB enriched three probiotic bacteria and reduced abundances of species associated with negative effects. The PBO group demonstrated increased abundances of pathogenic species and reduced abundances of several beneficial species. This trial supports the potential of the PNB as a supplemental intervention in the treatment of PD; however, further investigation is warranted, with stricter diagnostic criteria, disease biomarkers and direct veterinary examination. |
| first_indexed | 2024-03-08T04:01:45Z |
| format | Article |
| id | doaj.art-8462bcd7ede14b1ea8f68a77c99e5d2f |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-08T04:01:45Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-8462bcd7ede14b1ea8f68a77c99e5d2f2024-02-09T15:06:44ZengMDPI AGAnimals2076-26152024-01-0114345310.3390/ani14030453A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned DogsDevon E. Tate0Jirayu Tanprasertsuk1Roshonda B. Jones2Heather Maughan3Anirikh Chakrabarti4Ehsan Khafipour5Sharon A. Norton6Justin Shmalberg7Ryan W. Honaker8NomNomNow Inc., Nashville, TN 37207, USANomNomNow Inc., Nashville, TN 37207, USANomNomNow Inc., Nashville, TN 37207, USARonin Institute, Montclair, NJ 07043, USACargill Inc., Wayzata, MN 55391, USACargill Inc., Wayzata, MN 55391, USACargill Inc., Wayzata, MN 55391, USADepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USANomNomNow Inc., Nashville, TN 37207, USAPruritic dermatitis (PD) is a common presentation of canine allergic skin diseases, with diversity in severity and treatment response due to complex etiopathogenesis. Evidence suggests the gut microbiota (GM) may contribute to the development of canine allergies. A 10-week double-blind randomized controlled trial evaluated a novel probiotic and nutraceutical blend (PNB) on clinical signs of skin allergy, health measures, and the GM of privately owned self-reported pruritic dogs. A total of 105 dogs were enrolled, with 62 included in pruritus and health analysis and 50 in microbiome analysis. The PNB supported greater improvement of owner-assessed clinical signs of PD at week 2 than the placebo (PBO). More dogs that received the PNB shifted to normal pruritus (digital PVAS10-N: <2) by week 4, compared to week 7 for the PBO. While a placebo effect was identified, clinical differences were supported by changes in the GM. The PNB enriched three probiotic bacteria and reduced abundances of species associated with negative effects. The PBO group demonstrated increased abundances of pathogenic species and reduced abundances of several beneficial species. This trial supports the potential of the PNB as a supplemental intervention in the treatment of PD; however, further investigation is warranted, with stricter diagnostic criteria, disease biomarkers and direct veterinary examination.https://www.mdpi.com/2076-2615/14/3/453pruritic dermatitisfecal microbiotaskin allergiespruritusdog |
| spellingShingle | Devon E. Tate Jirayu Tanprasertsuk Roshonda B. Jones Heather Maughan Anirikh Chakrabarti Ehsan Khafipour Sharon A. Norton Justin Shmalberg Ryan W. Honaker A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs Animals pruritic dermatitis fecal microbiota skin allergies pruritus dog |
| title | A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs |
| title_full | A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs |
| title_fullStr | A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs |
| title_full_unstemmed | A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs |
| title_short | A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs |
| title_sort | randomized controlled trial to evaluate the impact of a novel probiotic and nutraceutical supplement on pruritic dermatitis and the gut microbiota in privately owned dogs |
| topic | pruritic dermatitis fecal microbiota skin allergies pruritus dog |
| url | https://www.mdpi.com/2076-2615/14/3/453 |
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