Regulation of the Abundance of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2.
The switch between latency and the lytic cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) is controlled by the expression of virally encoded ORF50 protein. Thus far, the regulatory mechanism underlying the protein stability of ORF50 is unknown. Our earlier studies have demonstrated that...
Main Authors: | Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu, Pey-Jium Chang |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-10-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5047794?pdf=render |
Similar Items
-
Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein Represses Cellular MDM2 Expression via Suppressing the Sp1- and p53-Mediated Transactivation
by: Chia-I Lin, et al.
Published: (2022-08-01) -
Interaction and assembly of the DNA replication core proteins of Kaposi’s sarcoma-associated herpesvirus
by: Lee-Wen Chen, et al.
Published: (2023-12-01) -
Kaposi’s Sarcoma-Associated Herpesvirus ORF7 Is Essential for Virus Production
by: Yuki Iwaisako, et al.
Published: (2021-05-01) -
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.
by: Chang, Y, et al.
Published: (1996) -
Activation of RSK and ERK MAPK kinases by ORF45 of Kaposi's sarcoma-associated herpesvirus
by: Wu F, et al.
Published: (2009-06-01)