Design, synthesis, and biological evaluation of 6-methoxy-2-arylquinolines as potential P-glycoprotein inhibitors

Design, synthesis, and biological evaluation of 6-methoxy-2-arylquinolines as potential P-glycoprotein inhibitors

Objective(s): In the present study,a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. Materials and Methods: The cytotoxic activity of the synthesized compounds was evaluated against t...

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Bibliographic Details
Main Authors:	Sayyed Mohammad Abutorabzadeh, Fatemeh Mosafa, Farzin Hadizadeh, Razieh Ghodsi
Format:	Article
Language:	English
Published:	Mashhad University of Medical Sciences 2018-01-01
Series:	Iranian Journal of Basic Medical Sciences
Subjects:	Molecular docking P-glycoprotein P-gp inhibition Quinoline Synthesis
Online Access:	http://ijbms.mums.ac.ir/article_9917_8ed4de841fcb62e0e8ed927ed1bc91b4.pdf

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