Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India
Background: Triple-negative breast cancer (TNBC) is defined as absent expression of estrogen receptor (ER) and progesterone receptors and human epidermal growth factor receptors (HER2neu). These cancers are associated with poor prognosis. Aims and Objectives: We aimed at to study the clinicopatho...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-09-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/55167 |
| _version_ | 1797722210837725184 |
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| author | Rajashree Pradhan Sajeeb Mondal Mrinal Sikdar Sankha Chatterjee |
| author_facet | Rajashree Pradhan Sajeeb Mondal Mrinal Sikdar Sankha Chatterjee |
| author_sort | Rajashree Pradhan |
| collection | DOAJ |
| description | Background: Triple-negative breast cancer (TNBC) is defined as absent expression of estrogen receptor (ER) and progesterone receptors and human epidermal growth factor receptors (HER2neu). These cancers are associated with poor prognosis.
Aims and Objectives: We aimed at to study the clinicopathological profile and survival among women with TNBC.
Materials and Methods: The study was conducted over a period of 4 years. Surgical specimens of patients with breast cancer were analyzed histopathologically as well as immunohistochemical analysis for estrogen, progesterone, HER2neu, and Ki-67 index was also done. Statistical analysis was done using software version 20.0. Results were expressed in number and percentage. Comparison was done by x2 test. P=0.05 was considered statistically significant.
Results: In our study, 26.92% cases were of TNBC. Predominant age group affected was between 50 and 70 years. Most common histologic type was invasive carcinoma of no special type with higher grade (Grades 2 and 3) mostly with frequent nodal metastasis. Higher percentage of Ki-67 proliferation index and basal cytokeratin expression were associated with higher tumor grade and stage along with reduced short-term disease-free survival on follow-up.
Conclusion: TNBCs are usually of higher grade with frequent recurrences and distant metastasis. There are no widely accepted prognostic markers available. Panel of immunohistochemical markers should be used specially to categorize the basal-like breast cancer subtype among TNBCs for better clinical outcome. |
| first_indexed | 2024-03-12T09:45:11Z |
| format | Article |
| id | doaj.art-84662453ba9a4349868ae59ac5ac70be |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T09:45:11Z |
| publishDate | 2023-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-84662453ba9a4349868ae59ac5ac70be2023-09-02T12:59:07ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-09-01149193199https://doi.org/10.3126/ajms.v14i9.55167Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern IndiaRajashree Pradhan0https://orcid.org/0000-0001-6770-7367Sajeeb Mondal 1https://orcid.org/0000-0002-1597-8584Mrinal Sikdar 2https://orcid.org/0000-0002-4345-223XSankha Chatterjee 3https://orcid.org/0000-0001-5722-6906Associate Professor, Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India Associate Professor, Department of Pathology, Rampurhat Government Medical College and Hospital, Rampurhat, West Bengal, India Assistant Professor, Department of Pathology, R G Kar Medical College and Hospital, Kolkata, West Bengal, India Demonstrator, Department of Pathology, Rampurhat Government Medical College and Hospital, Rampurhat, West Bengal, India Background: Triple-negative breast cancer (TNBC) is defined as absent expression of estrogen receptor (ER) and progesterone receptors and human epidermal growth factor receptors (HER2neu). These cancers are associated with poor prognosis. Aims and Objectives: We aimed at to study the clinicopathological profile and survival among women with TNBC. Materials and Methods: The study was conducted over a period of 4 years. Surgical specimens of patients with breast cancer were analyzed histopathologically as well as immunohistochemical analysis for estrogen, progesterone, HER2neu, and Ki-67 index was also done. Statistical analysis was done using software version 20.0. Results were expressed in number and percentage. Comparison was done by x2 test. P=0.05 was considered statistically significant. Results: In our study, 26.92% cases were of TNBC. Predominant age group affected was between 50 and 70 years. Most common histologic type was invasive carcinoma of no special type with higher grade (Grades 2 and 3) mostly with frequent nodal metastasis. Higher percentage of Ki-67 proliferation index and basal cytokeratin expression were associated with higher tumor grade and stage along with reduced short-term disease-free survival on follow-up. Conclusion: TNBCs are usually of higher grade with frequent recurrences and distant metastasis. There are no widely accepted prognostic markers available. Panel of immunohistochemical markers should be used specially to categorize the basal-like breast cancer subtype among TNBCs for better clinical outcome.https://www.nepjol.info/index.php/AJMS/article/view/55167basal-like breast cancer; cytokeratin 5/6; ki-67 proliferation index; triple negative |
| spellingShingle | Rajashree Pradhan Sajeeb Mondal Mrinal Sikdar Sankha Chatterjee Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India Asian Journal of Medical Sciences basal-like breast cancer; cytokeratin 5/6; ki-67 proliferation index; triple negative |
| title | Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India |
| title_full | Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India |
| title_fullStr | Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India |
| title_full_unstemmed | Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India |
| title_short | Clinicopathologic study of triple-negative breast cancer with special reference to basal-like breast cancer phenotype in a tertiary care hospital of Eastern India |
| title_sort | clinicopathologic study of triple negative breast cancer with special reference to basal like breast cancer phenotype in a tertiary care hospital of eastern india |
| topic | basal-like breast cancer; cytokeratin 5/6; ki-67 proliferation index; triple negative |
| url | https://www.nepjol.info/index.php/AJMS/article/view/55167 |
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