Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program
The <i>APOE</i> gene polymorphism is associated with the risk of the development of several neurological disorders. The aim of the study was to investigate the association of the <i>APOE</i> gene polymorphism with depression in the white adult population aged 25–64 years in N...
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MDPI AG
2023-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/9/1306 |
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| author | Valery Gafarov Elena Gromova Elena Shakhtshneider Igor Gagulin Almira Gafarova |
| author_facet | Valery Gafarov Elena Gromova Elena Shakhtshneider Igor Gagulin Almira Gafarova |
| author_sort | Valery Gafarov |
| collection | DOAJ |
| description | The <i>APOE</i> gene polymorphism is associated with the risk of the development of several neurological disorders. The aim of the study was to investigate the association of the <i>APOE</i> gene polymorphism with depression in the white adult population aged 25–64 years in Novosibirsk (Western Siberia). The third screening of the WHO program “MONICA-psychosocial” was conducted in 1994–1995. In total, 403 men (the average age was 34 ± 0.4 years, the response was 71%) and 531 women (the average age was 35 ± 0.4 years, the response was 72%) of the open population of residents aged 25–64 years of the Oktyabrsky district of Novosibirsk were examined. The “MONICA-MOPSY” psychosocial questionnaire was used to assess depression. A high level of depression was found in 12.8% of the population: in 8.9% of men and in 15.8% of women. The frequencies of <i>APOE</i> gene polymorphism genotypes ε2/3, ε2/4, ε3/3, ε3/4, and ε4/4 were 14.9%, 3.1%, 61.6%, 17.5%, and 2.9%, respectively. Carrying the ε3/4 genotype of the <i>APOE</i> gene increased the odds of developing major depression by 2.167 times (95% CI 1.100–4.266) compared to carrying the ε3/3 genotype of the <i>APOE</i> gene in people without depression (χ<sup>2</sup> = 5.120 df = 1 <i>p</i> = 0.024). Carriers of the ε4 allele were 2.089 times (95% CI 1.160–3.761) more likely to have a high level of depression than those without this allele and no depression (χ<sup>2</sup> = 6.148 df = 1 <i>p</i> = 0.013), and 2.049 times (95% CI 1.117–3.758) more likely to have a moderate level of depression than those without this allele (χ<sup>2</sup> = 5.470 df = 1 <i>p</i> < 0.019). The ε4 allele of the <i>APOE</i> gene is associated with a high level of depression. |
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| spelling | doaj.art-846662ee8e77449890f3000f21807c452023-11-19T11:30:24ZengMDPI AGJournal of Personalized Medicine2075-44262023-08-01139130610.3390/jpm13091306Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” ProgramValery Gafarov0Elena Gromova1Elena Shakhtshneider2Igor Gagulin3Almira Gafarova4Institute of Internal and Preventive Medicine (IIPM)-Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, RussiaInstitute of Internal and Preventive Medicine (IIPM)-Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, RussiaInstitute of Internal and Preventive Medicine (IIPM)-Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, RussiaInstitute of Internal and Preventive Medicine (IIPM)-Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, RussiaInstitute of Internal and Preventive Medicine (IIPM)-Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, RussiaThe <i>APOE</i> gene polymorphism is associated with the risk of the development of several neurological disorders. The aim of the study was to investigate the association of the <i>APOE</i> gene polymorphism with depression in the white adult population aged 25–64 years in Novosibirsk (Western Siberia). The third screening of the WHO program “MONICA-psychosocial” was conducted in 1994–1995. In total, 403 men (the average age was 34 ± 0.4 years, the response was 71%) and 531 women (the average age was 35 ± 0.4 years, the response was 72%) of the open population of residents aged 25–64 years of the Oktyabrsky district of Novosibirsk were examined. The “MONICA-MOPSY” psychosocial questionnaire was used to assess depression. A high level of depression was found in 12.8% of the population: in 8.9% of men and in 15.8% of women. The frequencies of <i>APOE</i> gene polymorphism genotypes ε2/3, ε2/4, ε3/3, ε3/4, and ε4/4 were 14.9%, 3.1%, 61.6%, 17.5%, and 2.9%, respectively. Carrying the ε3/4 genotype of the <i>APOE</i> gene increased the odds of developing major depression by 2.167 times (95% CI 1.100–4.266) compared to carrying the ε3/3 genotype of the <i>APOE</i> gene in people without depression (χ<sup>2</sup> = 5.120 df = 1 <i>p</i> = 0.024). Carriers of the ε4 allele were 2.089 times (95% CI 1.160–3.761) more likely to have a high level of depression than those without this allele and no depression (χ<sup>2</sup> = 6.148 df = 1 <i>p</i> = 0.013), and 2.049 times (95% CI 1.117–3.758) more likely to have a moderate level of depression than those without this allele (χ<sup>2</sup> = 5.470 df = 1 <i>p</i> < 0.019). The ε4 allele of the <i>APOE</i> gene is associated with a high level of depression.https://www.mdpi.com/2075-4426/13/9/1306<i>APOE</i> genedepressionε2/ε3/ε4 polymorphismrs7412rs429358 |
| spellingShingle | Valery Gafarov Elena Gromova Elena Shakhtshneider Igor Gagulin Almira Gafarova Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program Journal of Personalized Medicine <i>APOE</i> gene depression ε2/ε3/ε4 polymorphism rs7412 rs429358 |
| title | Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program |
| title_full | Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program |
| title_fullStr | Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program |
| title_full_unstemmed | Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program |
| title_short | Association of the <i>APOE</i> Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program |
| title_sort | association of the i apoe i gene polymorphism with depression in white adults in the who monica psychosocial program |
| topic | <i>APOE</i> gene depression ε2/ε3/ε4 polymorphism rs7412 rs429358 |
| url | https://www.mdpi.com/2075-4426/13/9/1306 |
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