Pregnancy outcomes according to increasing maternal age
Objectives: To investigate the risks of increasing maternal age on the perinatal and obstetric outcomes. Materials and Methods: Information about 29,760 singleton pregnancies delivered between 2005 and 2008 was extracted from our database. Patients were categorized into four groups according to age:...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-03-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455912000137 |
| _version_ | 1818409337020743680 |
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| author | Yu-Jin Koo Hyun-Mee Ryu Jae-Hyug Yang Ji-Hyae Lim Ji-Eun Lee Moon-Young Kim Jin-Hoon Chung |
| author_facet | Yu-Jin Koo Hyun-Mee Ryu Jae-Hyug Yang Ji-Hyae Lim Ji-Eun Lee Moon-Young Kim Jin-Hoon Chung |
| author_sort | Yu-Jin Koo |
| collection | DOAJ |
| description | Objectives: To investigate the risks of increasing maternal age on the perinatal and obstetric outcomes.
Materials and Methods: Information about 29,760 singleton pregnancies delivered between 2005 and 2008 was extracted from our database. Patients were categorized into four groups according to age: 20–29 years, 30–34 years, 35–39 years, and ≥40 years. Multivariable logistic regression analysis was used to evaluate the adjusted odd ratios (AORs) of adverse pregnancy outcomes according to maternal age after adjusting for parity, body mass index, medical history and use of in vitro fertilization.
Results: The majority of adverse perinatal outcomes were associated with a maternal age ≥35 years as follows: low birth weight (AOR 1.2 and 1.6 for women aged 35–39 years and ≥40 years, respectively); Apgar score < 7 at 1 minute (AOR: 1.7 and 1.8); and chromosomal anomaly (AOR: 2.7 and 12.3). However, women aged ≥30 years also had greater risks for adverse maternal outcomes such as: gestational diabetes (AOR: 2.0, 3.6 and 5.1 for women aged 30–34 years, 35–39 years and ≥40 years, respectively); placenta previa (AOR: 1.6, 2.1 and 3.6); and cesarean delivery (AOR: 1.5, 2.3, and 4.1), as well as adverse fetal outcomes such as: preterm delivery (AOR: 1.2, 1.4 and 1.8) and neonatal intensive care unit transfer (AOR: 1.1, 1.2, and 1.6).
Conclusion: Increasing maternal age is an independent and substantial risk factor for adverse perinatal and obstetric outcomes. These adverse outcomes become more common as increasing maternal age without a clear cutoff age. |
| first_indexed | 2024-12-14T09:58:01Z |
| format | Article |
| id | doaj.art-84674c7be9c8433eb80e30083ad51ca8 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-14T09:58:01Z |
| publishDate | 2012-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-84674c7be9c8433eb80e30083ad51ca82022-12-21T23:07:21ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592012-03-01511606510.1016/j.tjog.2012.01.012Pregnancy outcomes according to increasing maternal ageYu-Jin Koo0Hyun-Mee Ryu1Jae-Hyug Yang2Ji-Hyae Lim3Ji-Eun Lee4Moon-Young Kim5Jin-Hoon Chung6Department of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaDepartment of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaDepartment of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaLaboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaDepartment of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaDepartment of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaDepartment of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women’s Healthcare Center, Seoul, South KoreaObjectives: To investigate the risks of increasing maternal age on the perinatal and obstetric outcomes. Materials and Methods: Information about 29,760 singleton pregnancies delivered between 2005 and 2008 was extracted from our database. Patients were categorized into four groups according to age: 20–29 years, 30–34 years, 35–39 years, and ≥40 years. Multivariable logistic regression analysis was used to evaluate the adjusted odd ratios (AORs) of adverse pregnancy outcomes according to maternal age after adjusting for parity, body mass index, medical history and use of in vitro fertilization. Results: The majority of adverse perinatal outcomes were associated with a maternal age ≥35 years as follows: low birth weight (AOR 1.2 and 1.6 for women aged 35–39 years and ≥40 years, respectively); Apgar score < 7 at 1 minute (AOR: 1.7 and 1.8); and chromosomal anomaly (AOR: 2.7 and 12.3). However, women aged ≥30 years also had greater risks for adverse maternal outcomes such as: gestational diabetes (AOR: 2.0, 3.6 and 5.1 for women aged 30–34 years, 35–39 years and ≥40 years, respectively); placenta previa (AOR: 1.6, 2.1 and 3.6); and cesarean delivery (AOR: 1.5, 2.3, and 4.1), as well as adverse fetal outcomes such as: preterm delivery (AOR: 1.2, 1.4 and 1.8) and neonatal intensive care unit transfer (AOR: 1.1, 1.2, and 1.6). Conclusion: Increasing maternal age is an independent and substantial risk factor for adverse perinatal and obstetric outcomes. These adverse outcomes become more common as increasing maternal age without a clear cutoff age.http://www.sciencedirect.com/science/article/pii/S1028455912000137elderly pregnancymaternal agepregnancy outcome |
| spellingShingle | Yu-Jin Koo Hyun-Mee Ryu Jae-Hyug Yang Ji-Hyae Lim Ji-Eun Lee Moon-Young Kim Jin-Hoon Chung Pregnancy outcomes according to increasing maternal age Taiwanese Journal of Obstetrics & Gynecology elderly pregnancy maternal age pregnancy outcome |
| title | Pregnancy outcomes according to increasing maternal age |
| title_full | Pregnancy outcomes according to increasing maternal age |
| title_fullStr | Pregnancy outcomes according to increasing maternal age |
| title_full_unstemmed | Pregnancy outcomes according to increasing maternal age |
| title_short | Pregnancy outcomes according to increasing maternal age |
| title_sort | pregnancy outcomes according to increasing maternal age |
| topic | elderly pregnancy maternal age pregnancy outcome |
| url | http://www.sciencedirect.com/science/article/pii/S1028455912000137 |
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