Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis
Orthodontic tooth movement (OTM) involves mechanical–biochemical signal transduction, which results in tissue remodeling of the tooth–periodontium complex and the movement of orthodontic teeth. The dynamic regulation of osteogenesis and osteoclastogenesis serves as the biological basis for remodelin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1281250/full |
| _version_ | 1827387726551318528 |
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| author | Jing Ma Haixia Fan Haixia Geng |
| author_facet | Jing Ma Haixia Fan Haixia Geng |
| author_sort | Jing Ma |
| collection | DOAJ |
| description | Orthodontic tooth movement (OTM) involves mechanical–biochemical signal transduction, which results in tissue remodeling of the tooth–periodontium complex and the movement of orthodontic teeth. The dynamic regulation of osteogenesis and osteoclastogenesis serves as the biological basis for remodeling of the periodontium, and more importantly, the prerequisite for establishing periodontal homeostasis. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key effectors of the Hippo signaling pathway, which actively respond to mechanical stimuli during tooth movement. Specifically, they participate in translating mechanical into biochemical signals, thereby regulating periodontal homeostasis, periodontal remodeling, and tooth development. YAP and TAZ have widely been considered as key factors to prevent dental dysplasia, accelerate orthodontic tooth movement, and shorten treatment time. In this review, we summarize the functions of YAP and TAZ in regulating tooth development and periodontal remodeling, with the aim to gain a better understanding of their mechanisms of action and provide insights into maintaining proper tooth development and establishing a healthy periodontal and alveolar bone environment. Our findings offer novel perspectives and directions for targeted clinical treatments. Moreover, considering the similarities and differences in the development, structure, and physiology between YAP and TAZ, these molecules may exhibit functional variations in specific regulatory processes. Hence, we pay special attention to their distinct roles in specific regulatory functions to gain a comprehensive and profound understanding of their contributions. |
| first_indexed | 2024-03-08T16:06:31Z |
| format | Article |
| id | doaj.art-8467630c575d4a76ab5d00c586eb2389 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-08T16:06:31Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-8467630c575d4a76ab5d00c586eb23892024-01-08T05:29:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-01-011110.3389/fcell.2023.12812501281250Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasisJing Ma0Haixia Fan1Haixia Geng2Department of Oral Medicine, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Oral Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Orthodontics, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaOrthodontic tooth movement (OTM) involves mechanical–biochemical signal transduction, which results in tissue remodeling of the tooth–periodontium complex and the movement of orthodontic teeth. The dynamic regulation of osteogenesis and osteoclastogenesis serves as the biological basis for remodeling of the periodontium, and more importantly, the prerequisite for establishing periodontal homeostasis. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key effectors of the Hippo signaling pathway, which actively respond to mechanical stimuli during tooth movement. Specifically, they participate in translating mechanical into biochemical signals, thereby regulating periodontal homeostasis, periodontal remodeling, and tooth development. YAP and TAZ have widely been considered as key factors to prevent dental dysplasia, accelerate orthodontic tooth movement, and shorten treatment time. In this review, we summarize the functions of YAP and TAZ in regulating tooth development and periodontal remodeling, with the aim to gain a better understanding of their mechanisms of action and provide insights into maintaining proper tooth development and establishing a healthy periodontal and alveolar bone environment. Our findings offer novel perspectives and directions for targeted clinical treatments. Moreover, considering the similarities and differences in the development, structure, and physiology between YAP and TAZ, these molecules may exhibit functional variations in specific regulatory processes. Hence, we pay special attention to their distinct roles in specific regulatory functions to gain a comprehensive and profound understanding of their contributions.https://www.frontiersin.org/articles/10.3389/fcell.2023.1281250/fullorthodontic tooth movementYAPTAZtooth developmentperiodontal homeostasistissue remodeling |
| spellingShingle | Jing Ma Haixia Fan Haixia Geng Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis Frontiers in Cell and Developmental Biology orthodontic tooth movement YAP TAZ tooth development periodontal homeostasis tissue remodeling |
| title | Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis |
| title_full | Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis |
| title_fullStr | Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis |
| title_full_unstemmed | Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis |
| title_short | Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis |
| title_sort | distinct and overlapping functions of yap and taz in tooth development and periodontal homeostasis |
| topic | orthodontic tooth movement YAP TAZ tooth development periodontal homeostasis tissue remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1281250/full |
| work_keys_str_mv | AT jingma distinctandoverlappingfunctionsofyapandtazintoothdevelopmentandperiodontalhomeostasis AT haixiafan distinctandoverlappingfunctionsofyapandtazintoothdevelopmentandperiodontalhomeostasis AT haixiageng distinctandoverlappingfunctionsofyapandtazintoothdevelopmentandperiodontalhomeostasis |