The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury.
Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of UNC5B during an acute inflammatory response we inv...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3405071?pdf=render |
| _version_ | 1811310363575058432 |
|---|---|
| author | Klemens König David Köhler Tiago Granja Carla Jennewein Nguyen Tran Valbona Mirakaj Friedemann Kröhnert Peter Rosenberger |
| author_facet | Klemens König David Köhler Tiago Granja Carla Jennewein Nguyen Tran Valbona Mirakaj Friedemann Kröhnert Peter Rosenberger |
| author_sort | Klemens König |
| collection | DOAJ |
| description | Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of UNC5B during an acute inflammatory response we investigated the role of UNC5B on acute hepatic IRI. We report here that UNC5B(+/-) mice display reduced hepatic IRI and neutrophil (PMN) infiltration compared to WT controls. This correlated with serum levels of lactate dehydrogenase (LDH), aspartate- (AST) and alanine- (ALT) aminotransferase, the presence of PMN within ischemic hepatic tissue, and serum levels of inflammatory cytokines. Moreover, injection of an anti-UNC5B antibody resulted in a significant reduction of hepatic IR injury. This was associated with reduced parameters of liver injury (LDH, ALT, AST) and accumulation of PMN within the injured hepatic tissue. In conclusion our studies demonstrate a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future. |
| first_indexed | 2024-04-13T09:57:39Z |
| format | Article |
| id | doaj.art-84677716c31c4a648354c9ab5923008d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T09:57:39Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-84677716c31c4a648354c9ab5923008d2022-12-22T02:51:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4108510.1371/journal.pone.0041085The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury.Klemens KönigDavid KöhlerTiago GranjaCarla JenneweinNguyen TranValbona MirakajFriedemann KröhnertPeter RosenbergerRecent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of UNC5B during an acute inflammatory response we investigated the role of UNC5B on acute hepatic IRI. We report here that UNC5B(+/-) mice display reduced hepatic IRI and neutrophil (PMN) infiltration compared to WT controls. This correlated with serum levels of lactate dehydrogenase (LDH), aspartate- (AST) and alanine- (ALT) aminotransferase, the presence of PMN within ischemic hepatic tissue, and serum levels of inflammatory cytokines. Moreover, injection of an anti-UNC5B antibody resulted in a significant reduction of hepatic IR injury. This was associated with reduced parameters of liver injury (LDH, ALT, AST) and accumulation of PMN within the injured hepatic tissue. In conclusion our studies demonstrate a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future.http://europepmc.org/articles/PMC3405071?pdf=render |
| spellingShingle | Klemens König David Köhler Tiago Granja Carla Jennewein Nguyen Tran Valbona Mirakaj Friedemann Kröhnert Peter Rosenberger The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. PLoS ONE |
| title | The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. |
| title_full | The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. |
| title_fullStr | The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. |
| title_full_unstemmed | The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. |
| title_short | The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. |
| title_sort | uncoordinated 5 homolog b receptor affects hepatic ischemia reperfusion injury |
| url | http://europepmc.org/articles/PMC3405071?pdf=render |
| work_keys_str_mv | AT klemenskonig theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT davidkohler theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT tiagogranja theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT carlajennewein theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT nguyentran theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT valbonamirakaj theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT friedemannkrohnert theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT peterrosenberger theuncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT klemenskonig uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT davidkohler uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT tiagogranja uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT carlajennewein uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT nguyentran uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT valbonamirakaj uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT friedemannkrohnert uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury AT peterrosenberger uncoordinated5homologbreceptoraffectshepaticischemiareperfusioninjury |