The genome of Streptococcus mitis B6--what is a commensal?
Streptococcus mitis is the closest relative of the major human pathogen S. pneumoniae. The 2,15 Mb sequence of the Streptococcus mitis B6 chromosome, an unusually high-level beta-lactam resistant and multiple antibiotic resistant strain, has now been determined to encode 2100 genes. The accessory ge...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2828477?pdf=render |
| _version_ | 1811274513981112320 |
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| author | Dalia Denapaite Reinhold Brückner Michael Nuhn Peter Reichmann Bernhard Henrich Patrick Maurer Yvonne Schähle Peter Selbmann Wolfgang Zimmermann Rolf Wambutt Regine Hakenbeck |
| author_facet | Dalia Denapaite Reinhold Brückner Michael Nuhn Peter Reichmann Bernhard Henrich Patrick Maurer Yvonne Schähle Peter Selbmann Wolfgang Zimmermann Rolf Wambutt Regine Hakenbeck |
| author_sort | Dalia Denapaite |
| collection | DOAJ |
| description | Streptococcus mitis is the closest relative of the major human pathogen S. pneumoniae. The 2,15 Mb sequence of the Streptococcus mitis B6 chromosome, an unusually high-level beta-lactam resistant and multiple antibiotic resistant strain, has now been determined to encode 2100 genes. The accessory genome is estimated to represent over 40%, including 75 mostly novel transposases and IS, the prophage phiB6 and another seven phage related regions. Tetracycline resistance mediated by Tn5801, and an unusual and large gene cluster containing three aminoglycoside resistance determinants have not been described in other Streptococcus spp. Comparative genomic analyses including hybridization experiments on a S. mitis B6 specific microarray reveal that individual S. mitis strains are almost as distantly related to the B6 strain as S. pneumoniae. Both species share a core of over 900 genes. Most proteins described as pneumococcal virulence factors are present in S. mitis B6, but the three choline binding proteins PcpA, PspA and PspC, and three gene clusters containing the hyaluronidase gene, ply and lytA, and the capsular genes are absent in S. mitis B6 and other S. mitis as well and confirm their importance for the pathogenetic potential of S. pneumoniae. Despite the close relatedness between the two species, the S. mitis B6 genome reveals a striking X-alignment when compared with S. pneumoniae. |
| first_indexed | 2024-04-12T23:20:33Z |
| format | Article |
| id | doaj.art-8467dc0f5667424c9c212d815d6ac490 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T23:20:33Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8467dc0f5667424c9c212d815d6ac4902022-12-22T03:12:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0152e942610.1371/journal.pone.0009426The genome of Streptococcus mitis B6--what is a commensal?Dalia DenapaiteReinhold BrücknerMichael NuhnPeter ReichmannBernhard HenrichPatrick MaurerYvonne SchählePeter SelbmannWolfgang ZimmermannRolf WambuttRegine HakenbeckStreptococcus mitis is the closest relative of the major human pathogen S. pneumoniae. The 2,15 Mb sequence of the Streptococcus mitis B6 chromosome, an unusually high-level beta-lactam resistant and multiple antibiotic resistant strain, has now been determined to encode 2100 genes. The accessory genome is estimated to represent over 40%, including 75 mostly novel transposases and IS, the prophage phiB6 and another seven phage related regions. Tetracycline resistance mediated by Tn5801, and an unusual and large gene cluster containing three aminoglycoside resistance determinants have not been described in other Streptococcus spp. Comparative genomic analyses including hybridization experiments on a S. mitis B6 specific microarray reveal that individual S. mitis strains are almost as distantly related to the B6 strain as S. pneumoniae. Both species share a core of over 900 genes. Most proteins described as pneumococcal virulence factors are present in S. mitis B6, but the three choline binding proteins PcpA, PspA and PspC, and three gene clusters containing the hyaluronidase gene, ply and lytA, and the capsular genes are absent in S. mitis B6 and other S. mitis as well and confirm their importance for the pathogenetic potential of S. pneumoniae. Despite the close relatedness between the two species, the S. mitis B6 genome reveals a striking X-alignment when compared with S. pneumoniae.http://europepmc.org/articles/PMC2828477?pdf=render |
| spellingShingle | Dalia Denapaite Reinhold Brückner Michael Nuhn Peter Reichmann Bernhard Henrich Patrick Maurer Yvonne Schähle Peter Selbmann Wolfgang Zimmermann Rolf Wambutt Regine Hakenbeck The genome of Streptococcus mitis B6--what is a commensal? PLoS ONE |
| title | The genome of Streptococcus mitis B6--what is a commensal? |
| title_full | The genome of Streptococcus mitis B6--what is a commensal? |
| title_fullStr | The genome of Streptococcus mitis B6--what is a commensal? |
| title_full_unstemmed | The genome of Streptococcus mitis B6--what is a commensal? |
| title_short | The genome of Streptococcus mitis B6--what is a commensal? |
| title_sort | genome of streptococcus mitis b6 what is a commensal |
| url | http://europepmc.org/articles/PMC2828477?pdf=render |
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