Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men
Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified m...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-39865-9 |
| _version_ | 1797774093214285824 |
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| author | Tsion Zewdu Minas Brittany D. Lord Amy L. Zhang Julián Candia Tiffany H. Dorsey Francine S. Baker Wei Tang Maeve Bailey-Whyte Cheryl J. Smith Obadi M. Obadi Anuoluwapo Ajao Symone V. Jordan Yao Tettey Richard B. Biritwum Andrew A. Adjei James E. Mensah Robert N. Hoover Ann W. Hsing Jia Liu Christopher A. Loffredo Clayton Yates Michael B. Cook Stefan Ambs |
| author_facet | Tsion Zewdu Minas Brittany D. Lord Amy L. Zhang Julián Candia Tiffany H. Dorsey Francine S. Baker Wei Tang Maeve Bailey-Whyte Cheryl J. Smith Obadi M. Obadi Anuoluwapo Ajao Symone V. Jordan Yao Tettey Richard B. Biritwum Andrew A. Adjei James E. Mensah Robert N. Hoover Ann W. Hsing Jia Liu Christopher A. Loffredo Clayton Yates Michael B. Cook Stefan Ambs |
| author_sort | Tsion Zewdu Minas |
| collection | DOAJ |
| description | Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer. Blood levels of circulating fatty acids vary significantly between the three population groups, particularly trans, omega-3 and omega-6 fatty acids. FADS1/2 germline genetic variants and lifestyle factors explain some of the variation in fatty acid levels, with the FADS1/2 locus showing population-specific associations, suggesting differences in their control by germline genetic factors. All trans fatty acids, namely elaidic, palmitelaidic, and linoelaidic acids, associated with an increase in the odds of developing prostate cancer, independent of ancestry, geographic location, or potential confounders. |
| first_indexed | 2024-03-12T22:16:01Z |
| format | Article |
| id | doaj.art-84681ad62d1b40c89393fc3917165d7f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-12T22:16:01Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-84681ad62d1b40c89393fc3917165d7f2023-07-23T11:18:37ZengNature PortfolioNature Communications2041-17232023-07-0114111610.1038/s41467-023-39865-9Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American menTsion Zewdu Minas0Brittany D. Lord1Amy L. Zhang2Julián Candia3Tiffany H. Dorsey4Francine S. Baker5Wei Tang6Maeve Bailey-Whyte7Cheryl J. Smith8Obadi M. Obadi9Anuoluwapo Ajao10Symone V. Jordan11Yao Tettey12Richard B. Biritwum13Andrew A. Adjei14James E. Mensah15Robert N. Hoover16Ann W. Hsing17Jia Liu18Christopher A. Loffredo19Clayton Yates20Michael B. Cook21Stefan Ambs22Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)University of Ghana Medical SchoolUniversity of Ghana Medical SchoolUniversity of Ghana Medical SchoolUniversity of Ghana Medical SchoolDivision of Cancer Epidemiology & Genetics, NCIStanford Cancer Institute, Stanford UniversityCancer Genomics Research Laboratory, NCILombardi Comprehensive Cancer Center, Georgetown UniversityDepartment of Pathology, Johns Hopkins University School of MedicineDivision of Cancer Epidemiology & Genetics, NCILaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI)Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer. Blood levels of circulating fatty acids vary significantly between the three population groups, particularly trans, omega-3 and omega-6 fatty acids. FADS1/2 germline genetic variants and lifestyle factors explain some of the variation in fatty acid levels, with the FADS1/2 locus showing population-specific associations, suggesting differences in their control by germline genetic factors. All trans fatty acids, namely elaidic, palmitelaidic, and linoelaidic acids, associated with an increase in the odds of developing prostate cancer, independent of ancestry, geographic location, or potential confounders.https://doi.org/10.1038/s41467-023-39865-9 |
| spellingShingle | Tsion Zewdu Minas Brittany D. Lord Amy L. Zhang Julián Candia Tiffany H. Dorsey Francine S. Baker Wei Tang Maeve Bailey-Whyte Cheryl J. Smith Obadi M. Obadi Anuoluwapo Ajao Symone V. Jordan Yao Tettey Richard B. Biritwum Andrew A. Adjei James E. Mensah Robert N. Hoover Ann W. Hsing Jia Liu Christopher A. Loffredo Clayton Yates Michael B. Cook Stefan Ambs Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men Nature Communications |
| title | Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men |
| title_full | Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men |
| title_fullStr | Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men |
| title_full_unstemmed | Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men |
| title_short | Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men |
| title_sort | circulating trans fatty acids are associated with prostate cancer in ghanaian and american men |
| url | https://doi.org/10.1038/s41467-023-39865-9 |
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