Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes
Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16488-y |
| _version_ | 1818991356868034560 |
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| author | Shuhei Yoshida Sui Nishiyama Lisa Lister Shu Hashimoto Tappei Mishina Aurélien Courtois Hirohisa Kyogoku Takaya Abe Aki Shiraishi Meenakshi Choudhary Yoshiharu Nakaoka Mary Herbert Tomoya S. Kitajima |
| author_facet | Shuhei Yoshida Sui Nishiyama Lisa Lister Shu Hashimoto Tappei Mishina Aurélien Courtois Hirohisa Kyogoku Takaya Abe Aki Shiraishi Meenakshi Choudhary Yoshiharu Nakaoka Mary Herbert Tomoya S. Kitajima |
| author_sort | Shuhei Yoshida |
| collection | DOAJ |
| description | Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes. |
| first_indexed | 2024-12-20T20:08:58Z |
| format | Article |
| id | doaj.art-846a65e485104228b1fc63d20e3f1d9c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:08:58Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-846a65e485104228b1fc63d20e3f1d9c2022-12-21T19:27:52ZengNature PortfolioNature Communications2041-17232020-05-0111111510.1038/s41467-020-16488-yPrc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytesShuhei Yoshida0Sui Nishiyama1Lisa Lister2Shu Hashimoto3Tappei Mishina4Aurélien Courtois5Hirohisa Kyogoku6Takaya Abe7Aki Shiraishi8Meenakshi Choudhary9Yoshiharu Nakaoka10Mary Herbert11Tomoya S. Kitajima12Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Biosciences Institute, Newcastle University, Centre for Life, Times SquareLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research (BDR)Biosciences Institute, Newcastle University, Centre for Life, Times SquareIVF Namba ClinicBiosciences Institute, Newcastle University, Centre for Life, Times SquareLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes.https://doi.org/10.1038/s41467-020-16488-y |
| spellingShingle | Shuhei Yoshida Sui Nishiyama Lisa Lister Shu Hashimoto Tappei Mishina Aurélien Courtois Hirohisa Kyogoku Takaya Abe Aki Shiraishi Meenakshi Choudhary Yoshiharu Nakaoka Mary Herbert Tomoya S. Kitajima Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes Nature Communications |
| title | Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes |
| title_full | Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes |
| title_fullStr | Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes |
| title_full_unstemmed | Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes |
| title_short | Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes |
| title_sort | prc1 rich kinetochores are required for error free acentrosomal spindle bipolarization during meiosis i in mouse oocytes |
| url | https://doi.org/10.1038/s41467-020-16488-y |
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