Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion

Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion

Laryngeal cancer (LCa), a neoplasm of the head and neck region, is a leading cause of death worldwide. Surgical intervention remains the mainstay of LCa treatment, but a crucial point is represented by the possible nodal involvement. Therefore, it is urgently needed to develop biomarkers and therape...

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Bibliographic Details
Main Authors: Hiromichi Kawasaki, Takashi Takeuchi, Filippo Ricciardiello, Angela Lombardi, Elia Biganzoli, Marco Fornili, Davide De Bortoli, Massimo Mesolella, Alessia Maria Cossu, Marianna Scrima, Rosanna Capasso, Michela Falco, Giovanni Motta, Gaetano Motta, Domenico Testa, Stefania De Luca, Flavia Oliva, Teresa Abate, Salvatore Mazzone, Gabriella Misso, Michele Caraglia
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
microRNA
laryngeal cancer
metastases
miR-449a
miR-133b
migration
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301141

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