ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS
<em>Calotropis procera </em>is a species of <a title="Flowering plant" href="https://en.wikipedia.org/wiki/Flowering_plant">flowering plant</a>, in the family <a title="Apocynaceae" href="https://en.wikipedia.org/wiki/Apocynaceae">...
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| Format: | Article |
| Language: | English |
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Department of Food Technology
2021-12-01
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| Series: | Food ScienTech Journal |
| Online Access: | https://jurnal.untirta.ac.id/index.php/fsj/article/view/13344 |
| _version_ | 1797432639526797312 |
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| author | Olatunde A Oseni Hilda A Emmanuel-Akerele Wuraola A Adebayo |
| author_facet | Olatunde A Oseni Hilda A Emmanuel-Akerele Wuraola A Adebayo |
| author_sort | Olatunde A Oseni |
| collection | DOAJ |
| description | <em>Calotropis procera </em>is a species of <a title="Flowering plant" href="https://en.wikipedia.org/wiki/Flowering_plant">flowering plant</a>, in the family <a title="Apocynaceae" href="https://en.wikipedia.org/wiki/Apocynaceae"><em>Apocynaceae</em></a><em>, </em>the investigation of <em>Calotropis procera</em> for its medicinal usefulness has not been fully documented in the literatures. This study was therefore aimed at investigating the antimicrobial activity, phytochemical screening and acute toxicity of <em>Calotropis procera</em>. The antimicrobial activity, phytochemical screening and acute toxicity of the leaf was carried out using standard methods for the analyses. The antimicrobial activity of <em>Calotropis procera</em> leaf extract for bacterial showed that <em>Streptococcus pyogenes</em>, <em>Staphylococcus aureus</em>, <em>Escherichia coli</em> and <em>Aspergillus candideus</em> were resistant to the plant extract, while <em>Penicillum corylophilum</em> showed susceptibility to the plant extract. The phytochemical screening showed the presence of flavonoids, saponins and reducing sugar in the aqueous leaf extract of the leaf, while alkaloids and phlobatannins were absent in the extract of <em>Calotropis procera</em>. The acute toxicity investigation showed that <em>Calotropis procera</em> concentration at 1424 mg/kg body weight resulted in<em> </em>scratching and shivering but was not toxic to cause death of the mice, while lower concentrations of 142, 352, and 712 mg/kg body weight did not cause any observable negative reactions. The plant of <em>Calotropis procera</em> therefore showed that the aqueous extract of the plant contained viable phytochemicals compounds, potent antimicrobial activity to some organisms while the studied concentrations for acute toxicity were observed to be safe. |
| first_indexed | 2024-03-09T10:04:31Z |
| format | Article |
| id | doaj.art-846cbb4a4bde4b4490fd66e5b4a8ecac |
| institution | Directory Open Access Journal |
| issn | 2685-4279 2715-422X |
| language | English |
| last_indexed | 2024-03-09T10:04:31Z |
| publishDate | 2021-12-01 |
| publisher | Department of Food Technology |
| record_format | Article |
| series | Food ScienTech Journal |
| spelling | doaj.art-846cbb4a4bde4b4490fd66e5b4a8ecac2023-12-01T23:13:02ZengDepartment of Food TechnologyFood ScienTech Journal2685-42792715-422X2021-12-013212112610.33512/fsj.v3i2.133448047ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOSOlatunde A Oseni0Hilda A Emmanuel-Akerele1Wuraola A Adebayo2Department of Medical-Biochemistry, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, NigeriaDepartment of Biological Sciences, Faculty of Science and Science Education, Anchor University, Lagos, NigeriaDepartment of Chemical Sciences, Faculty of Science and Science Education, Anchor University, Lagos, Nigeria<em>Calotropis procera </em>is a species of <a title="Flowering plant" href="https://en.wikipedia.org/wiki/Flowering_plant">flowering plant</a>, in the family <a title="Apocynaceae" href="https://en.wikipedia.org/wiki/Apocynaceae"><em>Apocynaceae</em></a><em>, </em>the investigation of <em>Calotropis procera</em> for its medicinal usefulness has not been fully documented in the literatures. This study was therefore aimed at investigating the antimicrobial activity, phytochemical screening and acute toxicity of <em>Calotropis procera</em>. The antimicrobial activity, phytochemical screening and acute toxicity of the leaf was carried out using standard methods for the analyses. The antimicrobial activity of <em>Calotropis procera</em> leaf extract for bacterial showed that <em>Streptococcus pyogenes</em>, <em>Staphylococcus aureus</em>, <em>Escherichia coli</em> and <em>Aspergillus candideus</em> were resistant to the plant extract, while <em>Penicillum corylophilum</em> showed susceptibility to the plant extract. The phytochemical screening showed the presence of flavonoids, saponins and reducing sugar in the aqueous leaf extract of the leaf, while alkaloids and phlobatannins were absent in the extract of <em>Calotropis procera</em>. The acute toxicity investigation showed that <em>Calotropis procera</em> concentration at 1424 mg/kg body weight resulted in<em> </em>scratching and shivering but was not toxic to cause death of the mice, while lower concentrations of 142, 352, and 712 mg/kg body weight did not cause any observable negative reactions. The plant of <em>Calotropis procera</em> therefore showed that the aqueous extract of the plant contained viable phytochemicals compounds, potent antimicrobial activity to some organisms while the studied concentrations for acute toxicity were observed to be safe.https://jurnal.untirta.ac.id/index.php/fsj/article/view/13344 |
| spellingShingle | Olatunde A Oseni Hilda A Emmanuel-Akerele Wuraola A Adebayo ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS Food ScienTech Journal |
| title | ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS |
| title_full | ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS |
| title_fullStr | ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS |
| title_full_unstemmed | ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS |
| title_short | ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, LAGOS |
| title_sort | acute toxicity phytochemical screening and antimicrobial investigation of aqueous extract of sodom apple tree calotropis procera ait f leaf obtained within anchor university lagos |
| url | https://jurnal.untirta.ac.id/index.php/fsj/article/view/13344 |
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