The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome
Pseudoexfoliation syndrome (PEX) is an important systemic disorder of the extracellular matrix, in which granular amyloid-like protein fibers accumulate in the anterior segment of the eyeball as well as in other organs. PEX is currently considered to be a multifactorial systemic disorder with geneti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13234 |
| _version_ | 1797467929189548032 |
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| author | Martyna Tomczyk-Socha Wojciech Tomczak Anna Turno-Kręcicka |
| author_facet | Martyna Tomczyk-Socha Wojciech Tomczak Anna Turno-Kręcicka |
| author_sort | Martyna Tomczyk-Socha |
| collection | DOAJ |
| description | Pseudoexfoliation syndrome (PEX) is an important systemic disorder of the extracellular matrix, in which granular amyloid-like protein fibers accumulate in the anterior segment of the eyeball as well as in other organs. PEX is currently considered to be a multifactorial systemic disorder with genetic and environmental risk factors. The aim of this manuscript was to analyze miR expression in PEX. In recent years, an attempt has been made to investigate and describe the level of expression of selected miRs in PEX. Four polymorphisms of genes isolated from the blood that may be related to PEX were identified and miR-122-5p was found to be upregulated in patient blood. Furthermore, 18 miRs were identified with a statistically different expression in the aqueous humor. A significantly elevated expression of miR-125b was found in the anterior lens capsule, and four miRs were described, which may have a significant impact on the development of PEX. Regulatory miR molecules are gaining more and more importance in research aimed at identifying and isolating molecular markers related to the pathogenesis and prognosis of PEX, but further studies are needed. |
| first_indexed | 2024-03-09T19:00:45Z |
| format | Article |
| id | doaj.art-846f08ff159345dc8911f13ba9968fdd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-846f08ff159345dc8911f13ba9968fdd2023-11-24T05:04:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123211323410.3390/ijms232113234The Importance of MicroRNA Expression in Pseudoexfoliation SyndromeMartyna Tomczyk-Socha0Wojciech Tomczak1Anna Turno-Kręcicka2Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandStudents’ Scientific Society, Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandPseudoexfoliation syndrome (PEX) is an important systemic disorder of the extracellular matrix, in which granular amyloid-like protein fibers accumulate in the anterior segment of the eyeball as well as in other organs. PEX is currently considered to be a multifactorial systemic disorder with genetic and environmental risk factors. The aim of this manuscript was to analyze miR expression in PEX. In recent years, an attempt has been made to investigate and describe the level of expression of selected miRs in PEX. Four polymorphisms of genes isolated from the blood that may be related to PEX were identified and miR-122-5p was found to be upregulated in patient blood. Furthermore, 18 miRs were identified with a statistically different expression in the aqueous humor. A significantly elevated expression of miR-125b was found in the anterior lens capsule, and four miRs were described, which may have a significant impact on the development of PEX. Regulatory miR molecules are gaining more and more importance in research aimed at identifying and isolating molecular markers related to the pathogenesis and prognosis of PEX, but further studies are needed.https://www.mdpi.com/1422-0067/23/21/13234microRNAmiRpseudoexfoliation syndromeetiopathogenesis |
| spellingShingle | Martyna Tomczyk-Socha Wojciech Tomczak Anna Turno-Kręcicka The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome International Journal of Molecular Sciences microRNA miR pseudoexfoliation syndrome etiopathogenesis |
| title | The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome |
| title_full | The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome |
| title_fullStr | The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome |
| title_full_unstemmed | The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome |
| title_short | The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome |
| title_sort | importance of microrna expression in pseudoexfoliation syndrome |
| topic | microRNA miR pseudoexfoliation syndrome etiopathogenesis |
| url | https://www.mdpi.com/1422-0067/23/21/13234 |
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