Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis
Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, is a vital glycogen synthase regulator controlling glycogen synthesis, glucose metabolism, and insulin signaling. GSK-3 is widely expressed in different types of cells, and its abundant roles in cellular bioregulation have been speculate...
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/4669 |
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| author | Chia-Ling Chen Po-Chun Tseng Rahmat Dani Satria Thi Thuy Nguyen Cheng-Chieh Tsai Chiou-Feng Lin |
| author_facet | Chia-Ling Chen Po-Chun Tseng Rahmat Dani Satria Thi Thuy Nguyen Cheng-Chieh Tsai Chiou-Feng Lin |
| author_sort | Chia-Ling Chen |
| collection | DOAJ |
| description | Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, is a vital glycogen synthase regulator controlling glycogen synthesis, glucose metabolism, and insulin signaling. GSK-3 is widely expressed in different types of cells, and its abundant roles in cellular bioregulation have been speculated. Abnormal GSK-3 activation and inactivation may affect its original bioactivity. Moreover, active and inactive GSK-3 can regulate several cytosolic factors and modulate their diverse cellular functional roles. Studies in experimental liver disease models have illustrated the possible pathological role of GSK-3 in facilitating acute hepatic injury. Pharmacologically targeting GSK-3 is therefore suggested as a therapeutic strategy for liver protection. Furthermore, while the signaling transduction of GSK-3 facilitates proinflammatory interferon (IFN)-γ in vitro and in vivo, the blockade of GSK-3 can be protective, as shown by an IFN-γ-induced immune hepatitis model. In this study, we explored the possible regulation of GSK-3 and the potential relevance of GSK-3 blockade in IFN-γ-mediated immune hepatitis. |
| first_indexed | 2024-03-10T04:07:19Z |
| format | Article |
| id | doaj.art-84707c83e1ac42a09849b5f2b8aa0b0c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:07:19Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-84707c83e1ac42a09849b5f2b8aa0b0c2023-11-23T08:20:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239466910.3390/ijms23094669Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune HepatitisChia-Ling Chen0Po-Chun Tseng1Rahmat Dani Satria2Thi Thuy Nguyen3Cheng-Chieh Tsai4Chiou-Feng Lin5School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, TaiwanCore Laboratory of Immune Monitoring, Office of Research & Development, Taipei Medical University, Taipei 110, TaiwanInternational Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanInternational Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Nursing, Chung Hwa University of Medical Technology, Tainan 703, TaiwanCore Laboratory of Immune Monitoring, Office of Research & Development, Taipei Medical University, Taipei 110, TaiwanGlycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, is a vital glycogen synthase regulator controlling glycogen synthesis, glucose metabolism, and insulin signaling. GSK-3 is widely expressed in different types of cells, and its abundant roles in cellular bioregulation have been speculated. Abnormal GSK-3 activation and inactivation may affect its original bioactivity. Moreover, active and inactive GSK-3 can regulate several cytosolic factors and modulate their diverse cellular functional roles. Studies in experimental liver disease models have illustrated the possible pathological role of GSK-3 in facilitating acute hepatic injury. Pharmacologically targeting GSK-3 is therefore suggested as a therapeutic strategy for liver protection. Furthermore, while the signaling transduction of GSK-3 facilitates proinflammatory interferon (IFN)-γ in vitro and in vivo, the blockade of GSK-3 can be protective, as shown by an IFN-γ-induced immune hepatitis model. In this study, we explored the possible regulation of GSK-3 and the potential relevance of GSK-3 blockade in IFN-γ-mediated immune hepatitis.https://www.mdpi.com/1422-0067/23/9/4669glycogen synthase kinase-3immune hepatitisinterferon-γliver |
| spellingShingle | Chia-Ling Chen Po-Chun Tseng Rahmat Dani Satria Thi Thuy Nguyen Cheng-Chieh Tsai Chiou-Feng Lin Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis International Journal of Molecular Sciences glycogen synthase kinase-3 immune hepatitis interferon-γ liver |
| title | Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis |
| title_full | Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis |
| title_fullStr | Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis |
| title_full_unstemmed | Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis |
| title_short | Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis |
| title_sort | role of glycogen synthase kinase 3 in interferon γ mediated immune hepatitis |
| topic | glycogen synthase kinase-3 immune hepatitis interferon-γ liver |
| url | https://www.mdpi.com/1422-0067/23/9/4669 |
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