The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland
Background. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective...
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7494 |
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| author | Waldemar Brola Barbara Steinborn Marek Żak Maria Mazurkiewicz-Bełdzińska Sergiusz Jóźwiak Piotr Sobolewski Maciej Wilski Małgorzata Bilska Magdalena Siedlarska Iwona Puzio-Bochen Agnieszka Wencel-Warot Małgorzata Lemka Sławomir Kroczka Elżbieta Czyżyk Małgorzata Bocheńska Ewa Emich-Widera Jerzy Pietruszewski Leszek Boćkowski Katarzyna Kapica-Topczewska Agata Czarnowska Alina Kułakowska Barbara Ujma-Czapska Agata Gruna-Ożarowska Łukasz Przysło Katarzyna Połatyńska Magdalena Dudzińska Krystyna Mitosek-Szewczyk Aleksandra Melnyk Monika Adamczyk-Sowa Katarzyna Kotulska |
| author_facet | Waldemar Brola Barbara Steinborn Marek Żak Maria Mazurkiewicz-Bełdzińska Sergiusz Jóźwiak Piotr Sobolewski Maciej Wilski Małgorzata Bilska Magdalena Siedlarska Iwona Puzio-Bochen Agnieszka Wencel-Warot Małgorzata Lemka Sławomir Kroczka Elżbieta Czyżyk Małgorzata Bocheńska Ewa Emich-Widera Jerzy Pietruszewski Leszek Boćkowski Katarzyna Kapica-Topczewska Agata Czarnowska Alina Kułakowska Barbara Ujma-Czapska Agata Gruna-Ożarowska Łukasz Przysło Katarzyna Połatyńska Magdalena Dudzińska Krystyna Mitosek-Szewczyk Aleksandra Melnyk Monika Adamczyk-Sowa Katarzyna Kotulska |
| author_sort | Waldemar Brola |
| collection | DOAJ |
| description | Background. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective study was conducted based on the Polish Multiple Sclerosis Registry, considering a population of children and adolescents with MS (age ≤ 18 years). Data were collected by all 13 centres across Poland specializing in diagnosing and treating POMS. The actual course of the disease and its clinical properties were compared between child (≤12 years) and juvenile (>12 years) patients. MS onset and its prevalence were assessed at the end of 2019, stratified by age range. Results. A total of 329 paediatric or juvenile patients (228 girls, 101 boys) with a clinically definite diagnosis of MS, in conformity with the 2017 McDonald Criteria, were enrolled. For 71 children (21.6%), the first symptoms appeared before the age of 12. The female: male ratio increased with age, amounting to 1:1 in the ≤12 years group and to 2.9:1 in the >12 years group. In most cases, the disease had multi-symptomatic onset (31.3%), and its course was mostly of a relapsing–remitting character (95.7%). The initial Expanded Disability Status Score for both groups was 1.63 ± 1.1, whereas the annual relapse rate was 0.84 during the first 2 years. The time between the onset of symptoms and diagnosis was longer in the younger patients (8.2 ± 4.2 vs. 4.6 ± 3.6 months; <i>p</i> < 0.005). On 31 December 2019, the age-adjusted prevalence standardized to the European standard population was 5.19/100,000 (95% CI, 4.64–5.78). Significantly higher prevalence was noted in the 13–18 years group (7.12; 95% CI, 6.64–7.86) than in the 9–12 years group (3.41; 95% CI, 2.98–3.86) and the <9 years group (0.56; 95% CI, 0.46–0.64; <i>p</i> < 0.001). Conclusion. POMS commencing at the age of ≤12 years is rare, differing significantly from the juvenile-onset and adult MS in terms of clinical characteristics, course, and incidence, as stratified by gender. |
| first_indexed | 2024-03-09T16:15:55Z |
| format | Article |
| id | doaj.art-8474abeda82d40aca3681abc891a57da |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:15:55Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8474abeda82d40aca3681abc891a57da2023-11-24T15:46:34ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124749410.3390/jcm11247494The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in PolandWaldemar Brola0Barbara Steinborn1Marek Żak2Maria Mazurkiewicz-Bełdzińska3Sergiusz Jóźwiak4Piotr Sobolewski5Maciej Wilski6Małgorzata Bilska7Magdalena Siedlarska8Iwona Puzio-Bochen9Agnieszka Wencel-Warot10Małgorzata Lemka11Sławomir Kroczka12Elżbieta Czyżyk13Małgorzata Bocheńska14Ewa Emich-Widera15Jerzy Pietruszewski16Leszek Boćkowski17Katarzyna Kapica-Topczewska18Agata Czarnowska19Alina Kułakowska20Barbara Ujma-Czapska21Agata Gruna-Ożarowska22Łukasz Przysło23Katarzyna Połatyńska24Magdalena Dudzińska25Krystyna Mitosek-Szewczyk26Aleksandra Melnyk27Monika Adamczyk-Sowa28Katarzyna Kotulska29Collegium Medicum, Jan Kochanowski University, 25-369 Kielce, PolandDepartment of Developmental Neurology, Poznan University of Medical Sciences, 61-545 Poznań, PolandCollegium Medicum, Jan Kochanowski University, 25-369 Kielce, PolandDepartment of Developmental Neurology, Medical University of Gdańsk, 80-952 Gdańsk, PolandDepartment of Child Neurology, Medical University of Warsaw, 02-091 Warsaw, PolandCollegium Medicum, Jan Kochanowski University, 25-369 Kielce, PolandDepartment of Adapted Physical Activity, Poznań University of Physical Education, 61-871 Poznań, PolandDepartment of Child Neurology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Child Neurology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Neurology and Epileptology, The Children’s Memorial Health Institute, 04-783 Warsaw, PolandDepartment of Developmental Neurology, Poznan University of Medical Sciences, 61-545 Poznań, PolandDepartment of Developmental Neurology, Medical University of Gdańsk, 80-952 Gdańsk, PolandDepartment of Child and Adolescent Neurology, Medical College, Jagiellonian University in Kraków, 30-663 Kraków, PolandClinical Department of Child Neurology, Clinical Central Hospital No 2 in Rzeszow, 35-301 Rzeszów, PolandClinical Department of Child Neurology, Clinical Central Hospital No 2 in Rzeszow, 35-301 Rzeszów, PolandDepartment of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia Katowice, 41-808 Katowice, PolandDepartment of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia Katowice, 41-808 Katowice, PolandDepartment of Pediatric Neurology and Rehabilitation, Medical University of Białystok, 15-274 Białystok, PolandDepartment of Neurology, Medical University of Białystok, 15-276 Bialystok, PolandDepartment of Neurology, Medical University of Białystok, 15-276 Bialystok, PolandDepartment of Neurology, Medical University of Białystok, 15-276 Bialystok, PolandDepartment of Social Pediatrics, Faculty of Health Sciences, Wrocław Medical University, 51-618 Wrocław, PolandDepartment of Social Pediatrics, Faculty of Health Sciences, Wrocław Medical University, 51-618 Wrocław, PolandDepartment of Developmental Neurology, Polish Mother’s Memorial Hospital Research Institute, 93-338 Łódź, PolandDepartment of Developmental Neurology, Polish Mother’s Memorial Hospital Research Institute, 93-338 Łódź, PolandChildren’s Neurology Ward, Dr. E. Hanke Centre of Pediatrics and Oncology of Chorzów, 41-500 Chorzów, PolandDepartment of Child Neurology, Medical University, 20-093 Lublin, PolandDepartment of Child Neurology, Regional Specialized Children’s Hospital, Olsztyn, Poland, and Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, PolandDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Neurology and Epileptology, The Children’s Memorial Health Institute, 04-783 Warsaw, PolandBackground. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective study was conducted based on the Polish Multiple Sclerosis Registry, considering a population of children and adolescents with MS (age ≤ 18 years). Data were collected by all 13 centres across Poland specializing in diagnosing and treating POMS. The actual course of the disease and its clinical properties were compared between child (≤12 years) and juvenile (>12 years) patients. MS onset and its prevalence were assessed at the end of 2019, stratified by age range. Results. A total of 329 paediatric or juvenile patients (228 girls, 101 boys) with a clinically definite diagnosis of MS, in conformity with the 2017 McDonald Criteria, were enrolled. For 71 children (21.6%), the first symptoms appeared before the age of 12. The female: male ratio increased with age, amounting to 1:1 in the ≤12 years group and to 2.9:1 in the >12 years group. In most cases, the disease had multi-symptomatic onset (31.3%), and its course was mostly of a relapsing–remitting character (95.7%). The initial Expanded Disability Status Score for both groups was 1.63 ± 1.1, whereas the annual relapse rate was 0.84 during the first 2 years. The time between the onset of symptoms and diagnosis was longer in the younger patients (8.2 ± 4.2 vs. 4.6 ± 3.6 months; <i>p</i> < 0.005). On 31 December 2019, the age-adjusted prevalence standardized to the European standard population was 5.19/100,000 (95% CI, 4.64–5.78). Significantly higher prevalence was noted in the 13–18 years group (7.12; 95% CI, 6.64–7.86) than in the 9–12 years group (3.41; 95% CI, 2.98–3.86) and the <9 years group (0.56; 95% CI, 0.46–0.64; <i>p</i> < 0.001). Conclusion. POMS commencing at the age of ≤12 years is rare, differing significantly from the juvenile-onset and adult MS in terms of clinical characteristics, course, and incidence, as stratified by gender.https://www.mdpi.com/2077-0383/11/24/7494paediatric-onset multiple sclerosisclinical featureschildhood-onsetadolescent-onsetprevalence |
| spellingShingle | Waldemar Brola Barbara Steinborn Marek Żak Maria Mazurkiewicz-Bełdzińska Sergiusz Jóźwiak Piotr Sobolewski Maciej Wilski Małgorzata Bilska Magdalena Siedlarska Iwona Puzio-Bochen Agnieszka Wencel-Warot Małgorzata Lemka Sławomir Kroczka Elżbieta Czyżyk Małgorzata Bocheńska Ewa Emich-Widera Jerzy Pietruszewski Leszek Boćkowski Katarzyna Kapica-Topczewska Agata Czarnowska Alina Kułakowska Barbara Ujma-Czapska Agata Gruna-Ożarowska Łukasz Przysło Katarzyna Połatyńska Magdalena Dudzińska Krystyna Mitosek-Szewczyk Aleksandra Melnyk Monika Adamczyk-Sowa Katarzyna Kotulska The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland Journal of Clinical Medicine paediatric-onset multiple sclerosis clinical features childhood-onset adolescent-onset prevalence |
| title | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
| title_full | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
| title_fullStr | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
| title_full_unstemmed | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
| title_short | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
| title_sort | clinical and epidemiological profile of paediatric onset multiple sclerosis in poland |
| topic | paediatric-onset multiple sclerosis clinical features childhood-onset adolescent-onset prevalence |
| url | https://www.mdpi.com/2077-0383/11/24/7494 |
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