Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway

Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway

In order to examine the necessary structural features for a protein to promote lipid efflux by the ABCA1 transporter, synthetic peptides were tested on ABCA1-transfected cells (ABCA1 cells) and on control cells. L-37pA, an l amino acid peptide that contains two class-A amphipathic helices linked by...

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Bibliographic Details
Main Authors: Alan T. Remaley, Fairwell Thomas, John A. Stonik, Steve J. Demosky, Samantha E. Bark, Edward B. Neufeld, Alexander V. Bocharov, Tatyana G. Vishnyakova, Amy P. Patterson, Thomas L. Eggerman, Silvia Santamarina-Fojo, H.Bryan Brewer
Format: Article
Language:English
Published: Elsevier 2003-04-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter
apolipoprotein A-I
high density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311731

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