Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis
BackgroundObstructive sleep apnea syndrome (OSAS) may be associated with an increase in hypothalamic-pituitary-adrenocortical axis activity (HPA AA). We reviewed research comparing morning salivary and blood (serum and plasma) cortisol concentrations of individuals with OSAS to those of healthy cont...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.568823/full |
| _version_ | 1828974775262773248 |
|---|---|
| author | Mohammad Moslem Imani Masoud Sadeghi Habibolah Khazaie Arezoo Sanjabi Serge Brand Serge Brand Serge Brand Serge Brand Serge Brand Annette Brühl Dena Sadeghi Bahmani Dena Sadeghi Bahmani Dena Sadeghi Bahmani Dena Sadeghi Bahmani |
| author_facet | Mohammad Moslem Imani Masoud Sadeghi Habibolah Khazaie Arezoo Sanjabi Serge Brand Serge Brand Serge Brand Serge Brand Serge Brand Annette Brühl Dena Sadeghi Bahmani Dena Sadeghi Bahmani Dena Sadeghi Bahmani Dena Sadeghi Bahmani |
| author_sort | Mohammad Moslem Imani |
| collection | DOAJ |
| description | BackgroundObstructive sleep apnea syndrome (OSAS) may be associated with an increase in hypothalamic-pituitary-adrenocortical axis activity (HPA AA). We reviewed research comparing morning salivary and blood (serum and plasma) cortisol concentrations of individuals with OSAS to those of healthy controls.MethodsWe made a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases for relevant articles published up to August 25, 2019.ResultsSixteen studies were analyzed in this meta-analysis; five studies compared morning salivary concentrations, five compared serum concentrations, four compared plasma cortisol concentrations, and two compared both salivary and plasma concentrations. In pediatric samples, compared to healthy controls, those with OSAS had significantly lower saliva morning cortisol concentrations (MD = -0.13 µg/dl; 95% CI: 0.21, -0.04; P = 0.003). In contrast, no significant differences were observed for serum cortisol concentrations, plasma cortisol concentrations, or salivary morning cortisol concentrations between adults with and without OSAS (p = 0.61, p = 0.17, p = 0.17).ConclusionCortisol concentrations did not differ between adults with OSAS and healthy controls. In contrast, morning salivary cortisol concentrations were lower in children with OSAS, compared to healthy controls. Given that a reduced HPA AA is observed among individuals with chronic stress, it is conceivable that children with OSAS are experiencing chronic psychophysiological stress. |
| first_indexed | 2024-12-14T14:09:02Z |
| format | Article |
| id | doaj.art-847863f3afa942df98f43ad7689bf7a2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T14:09:02Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-847863f3afa942df98f43ad7689bf7a22022-12-21T22:58:23ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-01-011110.3389/fendo.2020.568823568823Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-AnalysisMohammad Moslem Imani0Masoud Sadeghi1Habibolah Khazaie2Arezoo Sanjabi3Serge Brand4Serge Brand5Serge Brand6Serge Brand7Serge Brand8Annette Brühl9Dena Sadeghi Bahmani10Dena Sadeghi Bahmani11Dena Sadeghi Bahmani12Dena Sadeghi Bahmani13Kermanshah University of Medical Sciences, Department of Orthodontics, Kermanshah, IranKermanshah University of Medical Sciences, Medical Biology Research Center, Kermanshah, IranKermanshah University of Medical Sciences, Sleep Disorders Research Center, Kermanshah, IranKermanshah University of Medical Sciences, Students Research Committee, Kermanshah, IranKermanshah University of Medical Sciences, Sleep Disorders Research Center, Kermanshah, IranUniversity of Basel, Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, Basel, SwitzerlandUniversity of Basel, Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, Basel, SwitzerlandKermanshah University of Medical Sciences, Substance Abuse Prevention Research Center, Kermanshah, IranTehran University of Medical Sciences, School of Medicine, Tehran, IranUniversity of Basel, Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, Basel, SwitzerlandKermanshah University of Medical Sciences, Sleep Disorders Research Center, Kermanshah, IranUniversity of Basel, Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, Basel, SwitzerlandKermanshah University of Medical Sciences, Substance Abuse Prevention Research Center, Kermanshah, IranUniversity of Basel, Psychiatric Clinics, Old Age Department, Basel, SwitzerlandBackgroundObstructive sleep apnea syndrome (OSAS) may be associated with an increase in hypothalamic-pituitary-adrenocortical axis activity (HPA AA). We reviewed research comparing morning salivary and blood (serum and plasma) cortisol concentrations of individuals with OSAS to those of healthy controls.MethodsWe made a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases for relevant articles published up to August 25, 2019.ResultsSixteen studies were analyzed in this meta-analysis; five studies compared morning salivary concentrations, five compared serum concentrations, four compared plasma cortisol concentrations, and two compared both salivary and plasma concentrations. In pediatric samples, compared to healthy controls, those with OSAS had significantly lower saliva morning cortisol concentrations (MD = -0.13 µg/dl; 95% CI: 0.21, -0.04; P = 0.003). In contrast, no significant differences were observed for serum cortisol concentrations, plasma cortisol concentrations, or salivary morning cortisol concentrations between adults with and without OSAS (p = 0.61, p = 0.17, p = 0.17).ConclusionCortisol concentrations did not differ between adults with OSAS and healthy controls. In contrast, morning salivary cortisol concentrations were lower in children with OSAS, compared to healthy controls. Given that a reduced HPA AA is observed among individuals with chronic stress, it is conceivable that children with OSAS are experiencing chronic psychophysiological stress.https://www.frontiersin.org/articles/10.3389/fendo.2020.568823/fullcortisolserumplasmasleepobstructive sleep apnea syndromesaliva |
| spellingShingle | Mohammad Moslem Imani Masoud Sadeghi Habibolah Khazaie Arezoo Sanjabi Serge Brand Serge Brand Serge Brand Serge Brand Serge Brand Annette Brühl Dena Sadeghi Bahmani Dena Sadeghi Bahmani Dena Sadeghi Bahmani Dena Sadeghi Bahmani Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis Frontiers in Endocrinology cortisol serum plasma sleep obstructive sleep apnea syndrome saliva |
| title | Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis |
| title_full | Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis |
| title_fullStr | Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis |
| title_full_unstemmed | Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis |
| title_short | Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis |
| title_sort | associations between morning salivary and blood cortisol concentrations in individuals with obstructive sleep apnea syndrome a meta analysis |
| topic | cortisol serum plasma sleep obstructive sleep apnea syndrome saliva |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.568823/full |
| work_keys_str_mv | AT mohammadmoslemimani associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT masoudsadeghi associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT habibolahkhazaie associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT arezoosanjabi associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT sergebrand associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT sergebrand associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT sergebrand associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT sergebrand associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT sergebrand associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT annettebruhl associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT denasadeghibahmani associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT denasadeghibahmani associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT denasadeghibahmani associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis AT denasadeghibahmani associationsbetweenmorningsalivaryandbloodcortisolconcentrationsinindividualswithobstructivesleepapneasyndromeametaanalysis |