Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin
Inducible Nitric Oxide Synthase (iNOS) is a key mediator in a variety of diseases, and thus it is interesting to discover new iNOS inhibitors. This study aimed to evaluate if the hydroalcoholic leaf extract of Caryota urens (CULHA) consisting of rutin and umbelliferone prevents inflammation in respo...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947620300851 |
| _version_ | 1818905150621745152 |
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| author | Sujitha Balaji Kripa Kavasseri Ganesan |
| author_facet | Sujitha Balaji Kripa Kavasseri Ganesan |
| author_sort | Sujitha Balaji |
| collection | DOAJ |
| description | Inducible Nitric Oxide Synthase (iNOS) is a key mediator in a variety of diseases, and thus it is interesting to discover new iNOS inhibitors. This study aimed to evaluate if the hydroalcoholic leaf extract of Caryota urens (CULHA) consisting of rutin and umbelliferone prevents inflammation in response to external stimuli. To demonstrate the therapeutic potential of CULHA against inflammatory diseases, nitric oxide production (NO) mediated by iNOS was evaluated. In lipopolysaccharide induced RAW 264.7 cells, CULHA, rutin and umbelliferone exhibited remarkable inhibition of NO at 61%, 30% and 41% respectively without affecting the cell viability at the highest concentration tested. In conclusion, results obtained in this work substantiate the traditional uses of this plant and brings a brief understanding of their anti inflammatory potential. |
| first_indexed | 2024-12-19T21:18:46Z |
| format | Article |
| id | doaj.art-8479e981d8cc4c068d20664dcd32419b |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-12-19T21:18:46Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-8479e981d8cc4c068d20664dcd32419b2022-12-21T20:05:17ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762021-04-01122369372Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutinSujitha Balaji0Kripa Kavasseri Ganesan1Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Chennai, 600 117, IndiaCorresponding author.; Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Chennai, 600 117, IndiaInducible Nitric Oxide Synthase (iNOS) is a key mediator in a variety of diseases, and thus it is interesting to discover new iNOS inhibitors. This study aimed to evaluate if the hydroalcoholic leaf extract of Caryota urens (CULHA) consisting of rutin and umbelliferone prevents inflammation in response to external stimuli. To demonstrate the therapeutic potential of CULHA against inflammatory diseases, nitric oxide production (NO) mediated by iNOS was evaluated. In lipopolysaccharide induced RAW 264.7 cells, CULHA, rutin and umbelliferone exhibited remarkable inhibition of NO at 61%, 30% and 41% respectively without affecting the cell viability at the highest concentration tested. In conclusion, results obtained in this work substantiate the traditional uses of this plant and brings a brief understanding of their anti inflammatory potential.http://www.sciencedirect.com/science/article/pii/S0975947620300851Caryota urensAnti-inflammatory activityRutinUmbelliferoneNitric oxideiNOS |
| spellingShingle | Sujitha Balaji Kripa Kavasseri Ganesan Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin Journal of Ayurveda and Integrative Medicine Caryota urens Anti-inflammatory activity Rutin Umbelliferone Nitric oxide iNOS |
| title | Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin |
| title_full | Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin |
| title_fullStr | Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin |
| title_full_unstemmed | Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin |
| title_short | Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin |
| title_sort | inhibition of inducible nitric oxide production by caryota urens and its active constituents umbelliferone and rutin |
| topic | Caryota urens Anti-inflammatory activity Rutin Umbelliferone Nitric oxide iNOS |
| url | http://www.sciencedirect.com/science/article/pii/S0975947620300851 |
| work_keys_str_mv | AT sujithabalaji inhibitionofinduciblenitricoxideproductionbycaryotaurensanditsactiveconstituentsumbelliferoneandrutin AT kripakavasseriganesan inhibitionofinduciblenitricoxideproductionbycaryotaurensanditsactiveconstituentsumbelliferoneandrutin |