An investigation about chronic prostatitis in ankylosing spondylitis
Abstract Background Chronic prostatitis has been a common disease reported with high frequency in ankylosing spondylitis (AS) even from decades ago. Infectious (Chlamydia trachomatis) or non-infectious (uric acid) prostatitis can hypothetically trigger vertebral inflammation in AS. This study aimed...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
|
| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-021-00180-w |
| _version_ | 1818961481947938816 |
|---|---|
| author | Eduardo Deves Rodrigo Novotny Fernando Hartmann Barazzetti Mara Cristina Scheffer Letícia Kramer Pacheco Adriana Fontes Zimmermann Ivânio Alves Pereira Maria Luiza Bazzo Fabricio Souza Neves |
| author_facet | Eduardo Deves Rodrigo Novotny Fernando Hartmann Barazzetti Mara Cristina Scheffer Letícia Kramer Pacheco Adriana Fontes Zimmermann Ivânio Alves Pereira Maria Luiza Bazzo Fabricio Souza Neves |
| author_sort | Eduardo Deves |
| collection | DOAJ |
| description | Abstract Background Chronic prostatitis has been a common disease reported with high frequency in ankylosing spondylitis (AS) even from decades ago. Infectious (Chlamydia trachomatis) or non-infectious (uric acid) prostatitis can hypothetically trigger vertebral inflammation in AS. This study aimed to assess the features of chronic prostatitis in patients with AS compared to healthy controls. Methods A cross-sectional study including male patients with AS and healthy controls who agreed to undergo a prostate examination was conducted. Structured clinical interviews, prostate physical examinations, and cytological, biochemical, and microbiological tests on urinary samples collected before and after standardized prostatic massage (pre- and post-massage test) were performed. Results Ninety participants (45 AS patients, mean age: 52.5 ± 10.0 years, with longstanding disease, 12.4 ± 6.9 years, and 45 controls, mean age: 52.8 ± 12.1 years) were included. National Institutes of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) scores were similar in the AS and control groups (4.0 [1.0–12.0] vs. 5.0 [1.0–8.5], p = 0.994). The frequencies of symptoms of chronic prostatitis (NIH-CPSI Pain Domain ≥4) were also similar in both groups (23.3% vs. 22.7%, p = 0.953). Results of polymerase chain reaction tests for Chlamydia trachomatis were negative in all tested urinary samples, and uric acid concentrations and leukocyte counts were similar in all pre- and post-massage urinary samples. Conclusions In this study, chronic prostatitis occurred in male patients with AS, but its frequency and characteristics did not differ from those found in the healthy male population of similar age. |
| first_indexed | 2024-12-20T12:14:07Z |
| format | Article |
| id | doaj.art-847c7d5f09fc4f1d8607c86da7cb5962 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-20T12:14:07Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-847c7d5f09fc4f1d8607c86da7cb59622022-12-21T19:41:12ZengBMCAdvances in Rheumatology2523-31062021-05-016111510.1186/s42358-021-00180-wAn investigation about chronic prostatitis in ankylosing spondylitisEduardo Deves0Rodrigo Novotny1Fernando Hartmann Barazzetti2Mara Cristina Scheffer3Letícia Kramer Pacheco4Adriana Fontes Zimmermann5Ivânio Alves Pereira6Maria Luiza Bazzo7Fabricio Souza Neves8Urology Service, University Hospital Prof. Polydoro Ernani de São Thiago HU/EBSERH, Federal University of Santa Catarina (UFSC)Urology Service, University Hospital Prof. Polydoro Ernani de São Thiago HU/EBSERH, Federal University of Santa Catarina (UFSC)Laboratory of Molecular Biology, Microbiology and Serology, Health Sciences Center (CCS), Federal University of Santa Catarina (UFSC)Laboratory of Molecular Biology, Microbiology and Serology, Health Sciences Center (CCS), Federal University of Santa Catarina (UFSC)Laboratory of Molecular Biology, Microbiology and Serology, Health Sciences Center (CCS), Federal University of Santa Catarina (UFSC)Rheumatology Unit, University Hospital Prof. Polydoro Ernani de São Thiago HU/EBSERH, Federal University of Santa Catarina (UFSC)Rheumatology Unit, University Hospital Prof. Polydoro Ernani de São Thiago HU/EBSERH, Federal University of Santa Catarina (UFSC)Laboratory of Molecular Biology, Microbiology and Serology, Health Sciences Center (CCS), Federal University of Santa Catarina (UFSC)Graduate Program in Medical Sciences (PPGCM), Health Sciences Center (CCS), Federal University of Santa Catarina (UFSC)Abstract Background Chronic prostatitis has been a common disease reported with high frequency in ankylosing spondylitis (AS) even from decades ago. Infectious (Chlamydia trachomatis) or non-infectious (uric acid) prostatitis can hypothetically trigger vertebral inflammation in AS. This study aimed to assess the features of chronic prostatitis in patients with AS compared to healthy controls. Methods A cross-sectional study including male patients with AS and healthy controls who agreed to undergo a prostate examination was conducted. Structured clinical interviews, prostate physical examinations, and cytological, biochemical, and microbiological tests on urinary samples collected before and after standardized prostatic massage (pre- and post-massage test) were performed. Results Ninety participants (45 AS patients, mean age: 52.5 ± 10.0 years, with longstanding disease, 12.4 ± 6.9 years, and 45 controls, mean age: 52.8 ± 12.1 years) were included. National Institutes of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) scores were similar in the AS and control groups (4.0 [1.0–12.0] vs. 5.0 [1.0–8.5], p = 0.994). The frequencies of symptoms of chronic prostatitis (NIH-CPSI Pain Domain ≥4) were also similar in both groups (23.3% vs. 22.7%, p = 0.953). Results of polymerase chain reaction tests for Chlamydia trachomatis were negative in all tested urinary samples, and uric acid concentrations and leukocyte counts were similar in all pre- and post-massage urinary samples. Conclusions In this study, chronic prostatitis occurred in male patients with AS, but its frequency and characteristics did not differ from those found in the healthy male population of similar age.https://doi.org/10.1186/s42358-021-00180-wAnkylosing spondylitisPelvic painProstatitisChlamydia trachomatisUric acid |
| spellingShingle | Eduardo Deves Rodrigo Novotny Fernando Hartmann Barazzetti Mara Cristina Scheffer Letícia Kramer Pacheco Adriana Fontes Zimmermann Ivânio Alves Pereira Maria Luiza Bazzo Fabricio Souza Neves An investigation about chronic prostatitis in ankylosing spondylitis Advances in Rheumatology Ankylosing spondylitis Pelvic pain Prostatitis Chlamydia trachomatis Uric acid |
| title | An investigation about chronic prostatitis in ankylosing spondylitis |
| title_full | An investigation about chronic prostatitis in ankylosing spondylitis |
| title_fullStr | An investigation about chronic prostatitis in ankylosing spondylitis |
| title_full_unstemmed | An investigation about chronic prostatitis in ankylosing spondylitis |
| title_short | An investigation about chronic prostatitis in ankylosing spondylitis |
| title_sort | investigation about chronic prostatitis in ankylosing spondylitis |
| topic | Ankylosing spondylitis Pelvic pain Prostatitis Chlamydia trachomatis Uric acid |
| url | https://doi.org/10.1186/s42358-021-00180-w |
| work_keys_str_mv | AT eduardodeves aninvestigationaboutchronicprostatitisinankylosingspondylitis AT rodrigonovotny aninvestigationaboutchronicprostatitisinankylosingspondylitis AT fernandohartmannbarazzetti aninvestigationaboutchronicprostatitisinankylosingspondylitis AT maracristinascheffer aninvestigationaboutchronicprostatitisinankylosingspondylitis AT leticiakramerpacheco aninvestigationaboutchronicprostatitisinankylosingspondylitis AT adrianafonteszimmermann aninvestigationaboutchronicprostatitisinankylosingspondylitis AT ivanioalvespereira aninvestigationaboutchronicprostatitisinankylosingspondylitis AT marialuizabazzo aninvestigationaboutchronicprostatitisinankylosingspondylitis AT fabriciosouzaneves aninvestigationaboutchronicprostatitisinankylosingspondylitis AT eduardodeves investigationaboutchronicprostatitisinankylosingspondylitis AT rodrigonovotny investigationaboutchronicprostatitisinankylosingspondylitis AT fernandohartmannbarazzetti investigationaboutchronicprostatitisinankylosingspondylitis AT maracristinascheffer investigationaboutchronicprostatitisinankylosingspondylitis AT leticiakramerpacheco investigationaboutchronicprostatitisinankylosingspondylitis AT adrianafonteszimmermann investigationaboutchronicprostatitisinankylosingspondylitis AT ivanioalvespereira investigationaboutchronicprostatitisinankylosingspondylitis AT marialuizabazzo investigationaboutchronicprostatitisinankylosingspondylitis AT fabriciosouzaneves investigationaboutchronicprostatitisinankylosingspondylitis |