Emerging Role of Non-Coding RNAs in Aortic Dissection
Aortic dissection (AD) is a fatal cardiovascular acute disease with high incidence and mortality, and it seriously threatens patients’ lives and health. The pathogenesis of AD mainly includes vascular inflammation, extracellular matrix degradation, and phenotypic conversion as well as apoptosis of v...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/10/1336 |
| _version_ | 1797474933507358720 |
|---|---|
| author | Wei Ding Ying Liu Zhe Su Qi Li Jianxun Wang Yufang Gao |
| author_facet | Wei Ding Ying Liu Zhe Su Qi Li Jianxun Wang Yufang Gao |
| author_sort | Wei Ding |
| collection | DOAJ |
| description | Aortic dissection (AD) is a fatal cardiovascular acute disease with high incidence and mortality, and it seriously threatens patients’ lives and health. The pathogenesis of AD mainly includes vascular inflammation, extracellular matrix degradation, and phenotypic conversion as well as apoptosis of vascular smooth muscle cells (VSMCs); however, its detailed mechanisms are still not fully elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are an emerging class of RNA molecules without protein-coding ability, and they play crucial roles in the progression of many diseases, including AD. A growing number of studies have shown that the dysregulation of ncRNAs contributes to the occurrence and development of AD by modulating the expression of specific target genes or the activity of related proteins. In addition, some ncRNAs exhibit great potential as promising biomarkers and therapeutic targets in AD treatment. In this review, we systematically summarize the recent findings on the underlying mechanism of ncRNA involved in AD regulation and highlight their clinical application as biomarkers and therapeutic targets in AD treatment. The information reviewed here will be of great benefit to the development of ncRNA-based therapeutic strategies for AD patients. |
| first_indexed | 2024-03-09T20:37:59Z |
| format | Article |
| id | doaj.art-847d916e2b1843b38632a48e46626422 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:37:59Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-847d916e2b1843b38632a48e466264222023-11-23T23:07:01ZengMDPI AGBiomolecules2218-273X2022-09-011210133610.3390/biom12101336Emerging Role of Non-Coding RNAs in Aortic DissectionWei Ding0Ying Liu1Zhe Su2Qi Li3Jianxun Wang4Yufang Gao5The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, ChinaSchool of Basic Medical Sciences, Qingdao Medical College, Qingdao University, Qingdao 266071, ChinaThe Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, ChinaSchool of Nursing, Qingdao Medical College, Qingdao University, Qingdao 266071, ChinaSchool of Basic Medical Sciences, Qingdao Medical College, Qingdao University, Qingdao 266071, ChinaThe Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, ChinaAortic dissection (AD) is a fatal cardiovascular acute disease with high incidence and mortality, and it seriously threatens patients’ lives and health. The pathogenesis of AD mainly includes vascular inflammation, extracellular matrix degradation, and phenotypic conversion as well as apoptosis of vascular smooth muscle cells (VSMCs); however, its detailed mechanisms are still not fully elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are an emerging class of RNA molecules without protein-coding ability, and they play crucial roles in the progression of many diseases, including AD. A growing number of studies have shown that the dysregulation of ncRNAs contributes to the occurrence and development of AD by modulating the expression of specific target genes or the activity of related proteins. In addition, some ncRNAs exhibit great potential as promising biomarkers and therapeutic targets in AD treatment. In this review, we systematically summarize the recent findings on the underlying mechanism of ncRNA involved in AD regulation and highlight their clinical application as biomarkers and therapeutic targets in AD treatment. The information reviewed here will be of great benefit to the development of ncRNA-based therapeutic strategies for AD patients.https://www.mdpi.com/2218-273X/12/10/1336aortic dissectionmicro RNAlong non-coding RNAcircular RNAbiomarkertherapeutic target |
| spellingShingle | Wei Ding Ying Liu Zhe Su Qi Li Jianxun Wang Yufang Gao Emerging Role of Non-Coding RNAs in Aortic Dissection Biomolecules aortic dissection micro RNA long non-coding RNA circular RNA biomarker therapeutic target |
| title | Emerging Role of Non-Coding RNAs in Aortic Dissection |
| title_full | Emerging Role of Non-Coding RNAs in Aortic Dissection |
| title_fullStr | Emerging Role of Non-Coding RNAs in Aortic Dissection |
| title_full_unstemmed | Emerging Role of Non-Coding RNAs in Aortic Dissection |
| title_short | Emerging Role of Non-Coding RNAs in Aortic Dissection |
| title_sort | emerging role of non coding rnas in aortic dissection |
| topic | aortic dissection micro RNA long non-coding RNA circular RNA biomarker therapeutic target |
| url | https://www.mdpi.com/2218-273X/12/10/1336 |
| work_keys_str_mv | AT weiding emergingroleofnoncodingrnasinaorticdissection AT yingliu emergingroleofnoncodingrnasinaorticdissection AT zhesu emergingroleofnoncodingrnasinaorticdissection AT qili emergingroleofnoncodingrnasinaorticdissection AT jianxunwang emergingroleofnoncodingrnasinaorticdissection AT yufanggao emergingroleofnoncodingrnasinaorticdissection |