The Role of Androgens and Androgen Receptor in Human Bladder Cancer
Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have a higher risk (4:1) of developing bladder cancer than women. Cigarette smoking and ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/4/594 |
| _version_ | 1797537262520500224 |
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| author | Elizabeth Martínez-Rojo Laura Cristina Berumen Guadalupe García-Alcocer Jesica Escobar-Cabrera |
| author_facet | Elizabeth Martínez-Rojo Laura Cristina Berumen Guadalupe García-Alcocer Jesica Escobar-Cabrera |
| author_sort | Elizabeth Martínez-Rojo |
| collection | DOAJ |
| description | Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have a higher risk (4:1) of developing bladder cancer than women. Cigarette smoking and exposure to chemicals such as aromatic amines, and aniline dyes have been established as risk factors for bladder cancer and may contribute to the sex disparity. Male internal genitalia, including the urothelium and prostate, are derived from urothelial sinus endoderm; both tissues express the androgen receptor (AR). Several investigations have shown evidence that the AR plays an important role in the initiation and development of different types of cancer including bladder cancer. In this article, we summarize the available data that help to explain the role of the AR in the development and progression of bladder cancer, as well as the therapies used for its treatment. |
| first_indexed | 2024-03-10T12:12:39Z |
| format | Article |
| id | doaj.art-847dbd78689a45f8a32a234b538f3c94 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T12:12:39Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-847dbd78689a45f8a32a234b538f3c942023-11-21T16:04:45ZengMDPI AGBiomolecules2218-273X2021-04-0111459410.3390/biom11040594The Role of Androgens and Androgen Receptor in Human Bladder CancerElizabeth Martínez-Rojo0Laura Cristina Berumen1Guadalupe García-Alcocer2Jesica Escobar-Cabrera3Unidad de Investigación Genética, Posgrado en Ciencias Químico Biológicas, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, MexicoUnidad de Investigación Genética, Posgrado en Ciencias Químico Biológicas, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, MexicoUnidad de Investigación Genética, Posgrado en Ciencias Químico Biológicas, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, MexicoUnidad de Investigación Genética, Posgrado en Ciencias Químico Biológicas, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, MexicoBladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have a higher risk (4:1) of developing bladder cancer than women. Cigarette smoking and exposure to chemicals such as aromatic amines, and aniline dyes have been established as risk factors for bladder cancer and may contribute to the sex disparity. Male internal genitalia, including the urothelium and prostate, are derived from urothelial sinus endoderm; both tissues express the androgen receptor (AR). Several investigations have shown evidence that the AR plays an important role in the initiation and development of different types of cancer including bladder cancer. In this article, we summarize the available data that help to explain the role of the AR in the development and progression of bladder cancer, as well as the therapies used for its treatment.https://www.mdpi.com/2218-273X/11/4/594androgensandrogen receptorbladder cancersignaling pathwaystherapies |
| spellingShingle | Elizabeth Martínez-Rojo Laura Cristina Berumen Guadalupe García-Alcocer Jesica Escobar-Cabrera The Role of Androgens and Androgen Receptor in Human Bladder Cancer Biomolecules androgens androgen receptor bladder cancer signaling pathways therapies |
| title | The Role of Androgens and Androgen Receptor in Human Bladder Cancer |
| title_full | The Role of Androgens and Androgen Receptor in Human Bladder Cancer |
| title_fullStr | The Role of Androgens and Androgen Receptor in Human Bladder Cancer |
| title_full_unstemmed | The Role of Androgens and Androgen Receptor in Human Bladder Cancer |
| title_short | The Role of Androgens and Androgen Receptor in Human Bladder Cancer |
| title_sort | role of androgens and androgen receptor in human bladder cancer |
| topic | androgens androgen receptor bladder cancer signaling pathways therapies |
| url | https://www.mdpi.com/2218-273X/11/4/594 |
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