A Designed “Nested” Dimer of Cyanovirin-N Increases Antiviral Activity

A Designed “Nested” Dimer of Cyanovirin-N Increases Antiviral Activity

Cyanovirin-N (CV-N) is an antiviral lectin with potent activity against enveloped viruses, including HIV. The mechanism of action involves high affinity binding to mannose-rich glycans that decorate the surface of enveloped viruses. In the case of HIV, antiviral activity of CV-N is postulated to req...

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Bibliographic Details
Main Authors: Brian W. Woodrum, Jason Maxwell, Denysia M. Allen, Jennifer Wilson, Lauren R.H. Krumpe, Andrey A. Bobkov, R. Blake Hill, Karen V. Kibler, Barry R. O’Keefe, Giovanna Ghirlanda
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Viruses
Subjects:
Cyanovirin-N
antiviral lectins
glycan-binding proteins
oligomannose
gp120
Online Access:http://www.mdpi.com/1999-4915/8/6/158

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