Glomus tumor of the duodenum: a rare case report
Abstract Background Glomus tumors (GTs) are mesenchymal neoplastic lesions arising from the glomus bodies and generally occur in the fingers and toes. Gastrointestinal GTs are rare, and most of them originate from the stomach; however, GT arising from the duodenum is exceedingly rare. Case presentat...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-12-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-020-01084-5 |
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| author | Shin Sasaki Yuko Takami Yoshiyuki Wada Tomoki Ryu Hajime Imamura Hiroki Ureshino Minako Fujiwara Hideki Saitsu |
| author_facet | Shin Sasaki Yuko Takami Yoshiyuki Wada Tomoki Ryu Hajime Imamura Hiroki Ureshino Minako Fujiwara Hideki Saitsu |
| author_sort | Shin Sasaki |
| collection | DOAJ |
| description | Abstract Background Glomus tumors (GTs) are mesenchymal neoplastic lesions arising from the glomus bodies and generally occur in the fingers and toes. Gastrointestinal GTs are rare, and most of them originate from the stomach; however, GT arising from the duodenum is exceedingly rare. Case presentation A 68-year-old man was admitted due to abdominal pain. Endoscopy showed a round, smooth, elevated mass in the second portion of the duodenum with central ulceration. Abdominal contrast computed tomography showed a hypervascular tumor measuring 26 mm in diameter in the second portion of the duodenum, and pancreatic invasion was suspected. Endoscopic ultrasonography of the lesion confirmed a hypoechoic mass arising from the fourth layer of the duodenal wall. A biopsy was performed for central ulceration, and immunochemical studies showed positive results for smooth muscle actin (SMA) and negative results for S100, C-Kit, and CD34. Leiomyoma or gastrointestinal stromal tumor was suspected and pancreatoduodenectomy was performed. The specimen exhibited a vascular-rich tumor, 24 × 24 × 19 mm in size, with deep ulceration in the duodenum. Histological examination showed uniform small round cells with central nuclei and a pale cytoplasm (glomus cell) with perivascular proliferation. Immunochemical studies showed that the tumor was positive for SMA and collagen type IV, and negative for C-Kit, CD34, desmin, and S100. We diagnosed the tumor as a GT of the duodenum. Conclusion GTs of the duodenum are exceedingly rare, but should be considered in the differential diagnoses of duodenal submucosal lesions. |
| first_indexed | 2024-12-16T13:09:17Z |
| format | Article |
| id | doaj.art-847edc4721344e1aa980e4d548bdb8ce |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-16T13:09:17Z |
| publishDate | 2020-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-847edc4721344e1aa980e4d548bdb8ce2022-12-21T22:30:39ZengSpringerOpenSurgical Case Reports2198-77932020-12-01611610.1186/s40792-020-01084-5Glomus tumor of the duodenum: a rare case reportShin Sasaki0Yuko Takami1Yoshiyuki Wada2Tomoki Ryu3Hajime Imamura4Hiroki Ureshino5Minako Fujiwara6Hideki Saitsu7Department of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterDepartment of Pathology, National Hospital Organization Kyushu Medical CenterDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical CenterAbstract Background Glomus tumors (GTs) are mesenchymal neoplastic lesions arising from the glomus bodies and generally occur in the fingers and toes. Gastrointestinal GTs are rare, and most of them originate from the stomach; however, GT arising from the duodenum is exceedingly rare. Case presentation A 68-year-old man was admitted due to abdominal pain. Endoscopy showed a round, smooth, elevated mass in the second portion of the duodenum with central ulceration. Abdominal contrast computed tomography showed a hypervascular tumor measuring 26 mm in diameter in the second portion of the duodenum, and pancreatic invasion was suspected. Endoscopic ultrasonography of the lesion confirmed a hypoechoic mass arising from the fourth layer of the duodenal wall. A biopsy was performed for central ulceration, and immunochemical studies showed positive results for smooth muscle actin (SMA) and negative results for S100, C-Kit, and CD34. Leiomyoma or gastrointestinal stromal tumor was suspected and pancreatoduodenectomy was performed. The specimen exhibited a vascular-rich tumor, 24 × 24 × 19 mm in size, with deep ulceration in the duodenum. Histological examination showed uniform small round cells with central nuclei and a pale cytoplasm (glomus cell) with perivascular proliferation. Immunochemical studies showed that the tumor was positive for SMA and collagen type IV, and negative for C-Kit, CD34, desmin, and S100. We diagnosed the tumor as a GT of the duodenum. Conclusion GTs of the duodenum are exceedingly rare, but should be considered in the differential diagnoses of duodenal submucosal lesions.https://doi.org/10.1186/s40792-020-01084-5DuodenumGlomus tumorSubmucosal tumor |
| spellingShingle | Shin Sasaki Yuko Takami Yoshiyuki Wada Tomoki Ryu Hajime Imamura Hiroki Ureshino Minako Fujiwara Hideki Saitsu Glomus tumor of the duodenum: a rare case report Surgical Case Reports Duodenum Glomus tumor Submucosal tumor |
| title | Glomus tumor of the duodenum: a rare case report |
| title_full | Glomus tumor of the duodenum: a rare case report |
| title_fullStr | Glomus tumor of the duodenum: a rare case report |
| title_full_unstemmed | Glomus tumor of the duodenum: a rare case report |
| title_short | Glomus tumor of the duodenum: a rare case report |
| title_sort | glomus tumor of the duodenum a rare case report |
| topic | Duodenum Glomus tumor Submucosal tumor |
| url | https://doi.org/10.1186/s40792-020-01084-5 |
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