Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo
The genotoxic effect of amitraz (3.6 mg/kg b.m, 1.8 mg/kg b.m, 0.9 mg/kg b.m) on bone marrow cells of HAN strain mice was examined in vivo by following the frequency of numeric and structural chromosomal aberrations, while the cytostatic effect of the same preparation was followed through the mitoti...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, Belgrade
2006-01-01
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| Series: | Veterinarski Glasnik |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0350-2457/2006/0350-24570604163P.pdf |
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| author | Pejin Ivana I. Stanimirović Zoran Stevanović Jevrosima B. Kulišić Zoran |
| author_facet | Pejin Ivana I. Stanimirović Zoran Stevanović Jevrosima B. Kulišić Zoran |
| author_sort | Pejin Ivana I. |
| collection | DOAJ |
| description | The genotoxic effect of amitraz (3.6 mg/kg b.m, 1.8 mg/kg b.m, 0.9 mg/kg b.m) on bone marrow cells of HAN strain mice was examined in vivo by following the frequency of numeric and structural chromosomal aberrations, while the cytostatic effect of the same preparation was followed through the mitotic index. The first experimental dose (3.6 mg/kg b.m) caused a statistically significant (p<0.01) increase in the mitotic index, while the second (1.8 mg/kg b.m) and the third (0.9 mg/kg b.m.) experimental dose statistically significantly (p<0.01) decreased the value of the mitotic index in animals of both sexes. All the applied doses exhibited an ability to induce numeric (aneuploidy and polyploidy) and structural (Robertsonian translocation) chromosomal aberrations. It can be concluded on the basis of the obtained results that the examined substance exhibits a genotoxic dose-dependant effect. . |
| first_indexed | 2024-12-24T04:24:00Z |
| format | Article |
| id | doaj.art-847fac06c8144c04b17198a300187365 |
| institution | Directory Open Access Journal |
| issn | 0350-2457 2406-0771 |
| language | English |
| last_indexed | 2024-12-24T04:24:00Z |
| publishDate | 2006-01-01 |
| publisher | Faculty of Veterinary Medicine, Belgrade |
| record_format | Article |
| series | Veterinarski Glasnik |
| spelling | doaj.art-847fac06c8144c04b17198a3001873652022-12-21T17:15:41ZengFaculty of Veterinary Medicine, BelgradeVeterinarski Glasnik0350-24572406-07712006-01-01603-416317310.2298/VETGL0604163P0350-24570604163PEvaluation of genotoxic potential of amitraz by cytogenetic test in vivoPejin Ivana I.0Stanimirović Zoran1Stevanović Jevrosima B.2Kulišić Zoran3Katedra za biologiju, Fakultet veterinarske medicine, BeogradistaistaKatedra za parazitologiju, Fakultet veterinarske medicine, BeogradThe genotoxic effect of amitraz (3.6 mg/kg b.m, 1.8 mg/kg b.m, 0.9 mg/kg b.m) on bone marrow cells of HAN strain mice was examined in vivo by following the frequency of numeric and structural chromosomal aberrations, while the cytostatic effect of the same preparation was followed through the mitotic index. The first experimental dose (3.6 mg/kg b.m) caused a statistically significant (p<0.01) increase in the mitotic index, while the second (1.8 mg/kg b.m) and the third (0.9 mg/kg b.m.) experimental dose statistically significantly (p<0.01) decreased the value of the mitotic index in animals of both sexes. All the applied doses exhibited an ability to induce numeric (aneuploidy and polyploidy) and structural (Robertsonian translocation) chromosomal aberrations. It can be concluded on the basis of the obtained results that the examined substance exhibits a genotoxic dose-dependant effect. .http://www.doiserbia.nb.rs/img/doi/0350-2457/2006/0350-24570604163P.pdfamitrazgenotoxicitycytostatic effectmitotic indexstructural aberrationsnumeric aberrations |
| spellingShingle | Pejin Ivana I. Stanimirović Zoran Stevanović Jevrosima B. Kulišić Zoran Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo Veterinarski Glasnik amitraz genotoxicity cytostatic effect mitotic index structural aberrations numeric aberrations |
| title | Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo |
| title_full | Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo |
| title_fullStr | Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo |
| title_full_unstemmed | Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo |
| title_short | Evaluation of genotoxic potential of amitraz by cytogenetic test in vivo |
| title_sort | evaluation of genotoxic potential of amitraz by cytogenetic test in vivo |
| topic | amitraz genotoxicity cytostatic effect mitotic index structural aberrations numeric aberrations |
| url | http://www.doiserbia.nb.rs/img/doi/0350-2457/2006/0350-24570604163P.pdf |
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