Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine
Objective: To determine whether early toxic effects from hydroxychloroquine (HCQ) could be detected by spectral-domain optical coherence tomography (SD-OCT) before symtomatic visual loss occured. Materials and Methods: Fifteen subjects with a history of the chronic use of hydroxychloroquine monother...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=4;spage=168;epage=171;aulast=Ulviye |
| _version_ | 1818197317358977024 |
|---|---|
| author | Yigit Ulviye Tugcu Betul Tarakcioglu Hatice Nur Celik Selda |
| author_facet | Yigit Ulviye Tugcu Betul Tarakcioglu Hatice Nur Celik Selda |
| author_sort | Yigit Ulviye |
| collection | DOAJ |
| description | Objective: To determine whether early toxic effects from hydroxychloroquine (HCQ) could be detected by spectral-domain optical coherence tomography (SD-OCT) before symtomatic visual loss occured. Materials and Methods: Fifteen subjects with a history of the chronic use of hydroxychloroquine monotherapy for less than five years without fundus changes (group 1) and 15 visually normal healthy subjects (group 2) were enrolled in this study. All participants underwent systemic and ocular examination, visual field testing, and macular scan imaging using SD-OCT. Results: There were no significant differences in sex and ages between the groups (P > 0.05). Mean duration of HCQ usage in group 1 was 2.5 ± 1.34 (range:1-5) years. Visual field testing with central 10-2 threshold program was normal in all subjects. Inner retinal thickness in parafoveal and perifoveal area were found to be significantly lower in group 1 compared to group 2 (P < 0.01 for perifoveal, P < 0.05 for parafoveal retinal measurements). However, significant thinning was demonstrated only in full retinal thickness of perifoveal area in group 1 compared to group 2 (P: 0.013). Parafoveal and perifoveal inner retinal thickness measurements of inferior quadrants were significantly reduced in group 1 compared to group 2 (P < 0.01). Conclusion: Significant thinning of inner retinal layer especially in parafoveal and perifoveal areas in the absence of clinical fundus changes was observed in our study. We consider that SD-OCT may determine when inner retinal thinning starts in these patients and may contribute a quantitative approach to the early diagnosis and progression of retinal changes. |
| first_indexed | 2024-12-12T01:48:03Z |
| format | Article |
| id | doaj.art-8483cb1866584bad9d3b1665b0efd0ae |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-12T01:48:03Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-8483cb1866584bad9d3b1665b0efd0ae2022-12-22T00:42:32ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892013-01-0161416817110.4103/0301-4738.112161Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquineYigit UlviyeTugcu BetulTarakcioglu Hatice NurCelik SeldaObjective: To determine whether early toxic effects from hydroxychloroquine (HCQ) could be detected by spectral-domain optical coherence tomography (SD-OCT) before symtomatic visual loss occured. Materials and Methods: Fifteen subjects with a history of the chronic use of hydroxychloroquine monotherapy for less than five years without fundus changes (group 1) and 15 visually normal healthy subjects (group 2) were enrolled in this study. All participants underwent systemic and ocular examination, visual field testing, and macular scan imaging using SD-OCT. Results: There were no significant differences in sex and ages between the groups (P > 0.05). Mean duration of HCQ usage in group 1 was 2.5 ± 1.34 (range:1-5) years. Visual field testing with central 10-2 threshold program was normal in all subjects. Inner retinal thickness in parafoveal and perifoveal area were found to be significantly lower in group 1 compared to group 2 (P < 0.01 for perifoveal, P < 0.05 for parafoveal retinal measurements). However, significant thinning was demonstrated only in full retinal thickness of perifoveal area in group 1 compared to group 2 (P: 0.013). Parafoveal and perifoveal inner retinal thickness measurements of inferior quadrants were significantly reduced in group 1 compared to group 2 (P < 0.01). Conclusion: Significant thinning of inner retinal layer especially in parafoveal and perifoveal areas in the absence of clinical fundus changes was observed in our study. We consider that SD-OCT may determine when inner retinal thinning starts in these patients and may contribute a quantitative approach to the early diagnosis and progression of retinal changes.http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=4;spage=168;epage=171;aulast=UlviyeAmpiginous choroiditisfluorescein angiography/fluorescein angiogramindocyanine green angiogrammultifocal choroiditisposterior uveitisserpiginous choroiditisBranch retinal vein occlusionmean platelet volumeplatelet activationretinal vein occlusionFibrin glueglued intrascleral fixationglued intraocular lens forcepsthree-piece foldable intraocular lensHydroxychloroquineoptical coherence tomographyretinal toxicityretinal thickness |
| spellingShingle | Yigit Ulviye Tugcu Betul Tarakcioglu Hatice Nur Celik Selda Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine Indian Journal of Ophthalmology Ampiginous choroiditis fluorescein angiography/fluorescein angiogram indocyanine green angiogram multifocal choroiditis posterior uveitis serpiginous choroiditis Branch retinal vein occlusion mean platelet volume platelet activation retinal vein occlusion Fibrin glue glued intrascleral fixation glued intraocular lens forceps three-piece foldable intraocular lens Hydroxychloroquine optical coherence tomography retinal toxicity retinal thickness |
| title | Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine |
| title_full | Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine |
| title_fullStr | Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine |
| title_full_unstemmed | Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine |
| title_short | Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine |
| title_sort | spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine |
| topic | Ampiginous choroiditis fluorescein angiography/fluorescein angiogram indocyanine green angiogram multifocal choroiditis posterior uveitis serpiginous choroiditis Branch retinal vein occlusion mean platelet volume platelet activation retinal vein occlusion Fibrin glue glued intrascleral fixation glued intraocular lens forceps three-piece foldable intraocular lens Hydroxychloroquine optical coherence tomography retinal toxicity retinal thickness |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=4;spage=168;epage=171;aulast=Ulviye |
| work_keys_str_mv | AT yigitulviye spectraldomainopticalcoherencetomographyforearlydetectionofretinalalterationsinpatientsusinghydroxychloroquine AT tugcubetul spectraldomainopticalcoherencetomographyforearlydetectionofretinalalterationsinpatientsusinghydroxychloroquine AT tarakciogluhaticenur spectraldomainopticalcoherencetomographyforearlydetectionofretinalalterationsinpatientsusinghydroxychloroquine AT celikselda spectraldomainopticalcoherencetomographyforearlydetectionofretinalalterationsinpatientsusinghydroxychloroquine |