Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study
Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/20/6052 |
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| author | Yeong Jin Kim Tae-Kyu Lee Myung-Giun Noh Tae-Young Jung In-Young Kim Shin Jung Kyung-Hwa Lee Kyung-Sub Moon |
| author_facet | Yeong Jin Kim Tae-Kyu Lee Myung-Giun Noh Tae-Young Jung In-Young Kim Shin Jung Kyung-Hwa Lee Kyung-Sub Moon |
| author_sort | Yeong Jin Kim |
| collection | DOAJ |
| description | Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for at least 3 or 12 months (mos) after GBM diagnosis. Although GPC usage (≥3 mos) did not make significant differences in survival extension, median OS in the long-term GPC group (≥12 mos) was longer with statistical significance, compared to the control group (<12 mos) (38.3 vs. 24.0 mos, <i>p</i> = 0.004). In addition to younger age, supratentorial location, complete resection, and MGMT promoter methylation, long-term use of GPC (≥12 mos) was significantly associated with longer OS in multivariate analysis (<i>p</i> = 0.019, hazard ratio [HR] 0.532, 95% confidence interval [CI] 0.314–0.900). Despite the limitations of this study, long-term GPC use was possibly associated with prolonged survival in GBM patients. Multi-center prospective randomized studies with a large number of patients are needed to validate these findings. |
| first_indexed | 2024-03-09T20:02:59Z |
| format | Article |
| id | doaj.art-848466fe7c7c4746a407fad8104c44b5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:02:59Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-848466fe7c7c4746a407fad8104c44b52023-11-24T00:40:01ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011120605210.3390/jcm11206052Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center StudyYeong Jin Kim0Tae-Kyu Lee1Myung-Giun Noh2Tae-Young Jung3In-Young Kim4Shin Jung5Kyung-Hwa Lee6Kyung-Sub Moon7Departments of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Pathology, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Pathology, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartments of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Jeollanam-do, KoreaCognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for at least 3 or 12 months (mos) after GBM diagnosis. Although GPC usage (≥3 mos) did not make significant differences in survival extension, median OS in the long-term GPC group (≥12 mos) was longer with statistical significance, compared to the control group (<12 mos) (38.3 vs. 24.0 mos, <i>p</i> = 0.004). In addition to younger age, supratentorial location, complete resection, and MGMT promoter methylation, long-term use of GPC (≥12 mos) was significantly associated with longer OS in multivariate analysis (<i>p</i> = 0.019, hazard ratio [HR] 0.532, 95% confidence interval [CI] 0.314–0.900). Despite the limitations of this study, long-term GPC use was possibly associated with prolonged survival in GBM patients. Multi-center prospective randomized studies with a large number of patients are needed to validate these findings.https://www.mdpi.com/2077-0383/11/20/6052choline alphoscerateglioblastomaisocitrate dehydrongenase-wild-typesurvival |
| spellingShingle | Yeong Jin Kim Tae-Kyu Lee Myung-Giun Noh Tae-Young Jung In-Young Kim Shin Jung Kyung-Hwa Lee Kyung-Sub Moon Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study Journal of Clinical Medicine choline alphoscerate glioblastoma isocitrate dehydrongenase-wild-type survival |
| title | Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study |
| title_full | Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study |
| title_fullStr | Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study |
| title_full_unstemmed | Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study |
| title_short | Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study |
| title_sort | effect of choline alphoscerate on the survival of glioblastoma patients a retrospective single center study |
| topic | choline alphoscerate glioblastoma isocitrate dehydrongenase-wild-type survival |
| url | https://www.mdpi.com/2077-0383/11/20/6052 |
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