Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature
<b>Background:</b> Tall cell carcinoma of the breast with reversed polarity (TCCRP) is a rare type of invasive breast cancer with overlapping features with papillary thyroid carcinoma and a characteristic molecular profile. Few cases have been reported in the literature since the first c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2376 |
| _version_ | 1797581172620918784 |
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| author | Maiar Elghobashy Stephanie Jenkins Zachary Shulman Anne O’Neil Sofia Kouneli Abeer M. Shaaban |
| author_facet | Maiar Elghobashy Stephanie Jenkins Zachary Shulman Anne O’Neil Sofia Kouneli Abeer M. Shaaban |
| author_sort | Maiar Elghobashy |
| collection | DOAJ |
| description | <b>Background:</b> Tall cell carcinoma of the breast with reversed polarity (TCCRP) is a rare type of invasive breast cancer with overlapping features with papillary thyroid carcinoma and a characteristic molecular profile. Few cases have been reported in the literature since the first case was described in 2003. <b>Case presentation:</b> We present the case of a 41-year-old female with a symptomatic left breast lump. Image-guided core biopsy was diagnosed as triple-negative apocrine carcinoma. Surgical excision revealed an invasive carcinoma with solid papillary pattern, nuclei arranged away from the basement membrane (reversed polarity) and luminal eosinophilic colloid-like material. The tumour was GATA3-, CK5-, CK14- and CK7-positive and TTF1-negative. Specialist opinion and the identification of hotspot mutations in the <i>IDH2</i> p.Arg172 gene via PCR confirmed the diagnosis of TCCRP. <b>Conclusions:</b> TCCRP is a relatively recently recognised papillary epithelial neoplasm with characteristic morphological features and molecular profile. Due to its rarity, TCCRP can be diagnostically challenging, and features can be mistaken for benign and malignant lesions. Accurate diagnosis is important in effective treatment of this indolent malignant triple-negative breast cancer, which carries an excellent prognosis. |
| first_indexed | 2024-03-10T23:01:31Z |
| format | Article |
| id | doaj.art-84846a3c88da46c4b43dc844266a5c96 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:01:31Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-84846a3c88da46c4b43dc844266a5c962023-11-19T09:40:25ZengMDPI AGBiomedicines2227-90592023-08-01119237610.3390/biomedicines11092376Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the LiteratureMaiar Elghobashy0Stephanie Jenkins1Zachary Shulman2Anne O’Neil3Sofia Kouneli4Abeer M. Shaaban5The Royal Wolverhampton NHS Trust, Wolverhampton WV10 0QP, UKUniversity Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, UKUniversity Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, UKUniversity Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, UKUniversity Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, UKQueen Elizabeth Hospital Birmingham, University of Birmingham, Birmingham B15 2TT, UK<b>Background:</b> Tall cell carcinoma of the breast with reversed polarity (TCCRP) is a rare type of invasive breast cancer with overlapping features with papillary thyroid carcinoma and a characteristic molecular profile. Few cases have been reported in the literature since the first case was described in 2003. <b>Case presentation:</b> We present the case of a 41-year-old female with a symptomatic left breast lump. Image-guided core biopsy was diagnosed as triple-negative apocrine carcinoma. Surgical excision revealed an invasive carcinoma with solid papillary pattern, nuclei arranged away from the basement membrane (reversed polarity) and luminal eosinophilic colloid-like material. The tumour was GATA3-, CK5-, CK14- and CK7-positive and TTF1-negative. Specialist opinion and the identification of hotspot mutations in the <i>IDH2</i> p.Arg172 gene via PCR confirmed the diagnosis of TCCRP. <b>Conclusions:</b> TCCRP is a relatively recently recognised papillary epithelial neoplasm with characteristic morphological features and molecular profile. Due to its rarity, TCCRP can be diagnostically challenging, and features can be mistaken for benign and malignant lesions. Accurate diagnosis is important in effective treatment of this indolent malignant triple-negative breast cancer, which carries an excellent prognosis.https://www.mdpi.com/2227-9059/11/9/2376breast cancerreversed polaritytall cell carcinoma |
| spellingShingle | Maiar Elghobashy Stephanie Jenkins Zachary Shulman Anne O’Neil Sofia Kouneli Abeer M. Shaaban Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature Biomedicines breast cancer reversed polarity tall cell carcinoma |
| title | Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature |
| title_full | Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature |
| title_fullStr | Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature |
| title_full_unstemmed | Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature |
| title_short | Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature |
| title_sort | tall cell carcinoma with reversed polarity case report of a rare special type of breast cancer and review of the literature |
| topic | breast cancer reversed polarity tall cell carcinoma |
| url | https://www.mdpi.com/2227-9059/11/9/2376 |
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