Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

In response to physiological demand, the pituitary gland generates new hormone-secreting cells from committed progenitor cells throughout life. It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither th...

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Bibliographic Details
Main Authors: John P Russell, Xinhong Lim, Alice Santambrogio, Val Yianni, Yasmine Kemkem, Bruce Wang, Matthew Fish, Scott Haston, Anaëlle Grabek, Shirleen Hallang, Emily J Lodge, Amanda L Patist, Andreas Schedl, Patrice Mollard, Roel Nusse, Cynthia L Andoniadou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
SOX2
WNT
paracrine signal
pituitary gland
feedforward regulation
stem cell
Online Access:https://elifesciences.org/articles/59142

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