Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease
Alzheimer's disease (AD) is an age-related neurodegenerative disease with insidious onset and slow progression. The progression of AD from only brain pathological changes to clinically identifiable cognitive changes is affected by a variety of environmental factors inside and outside the organi...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-06-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-788.shtml |
| _version_ | 1797304007319879680 |
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| author | JIANG Xinting HUANG Gaozhong |
| author_facet | JIANG Xinting HUANG Gaozhong |
| author_sort | JIANG Xinting |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is an age-related neurodegenerative disease with insidious onset and slow progression. The progression of AD from only brain pathological changes to clinically identifiable cognitive changes is affected by a variety of environmental factors inside and outside the organism and can last for decades. Cognitive impairment is an important clinical feature of AD that impairs the quality of life of the elderly in their later years, and the available drugs for the treatment of AD have failed to cure the disease, indicating the importance of early prevention of AD-related cognitive impairment. Most current research on the relationship between nutrition and AD takes nutritional intervention as a preventive method for AD-related cognitive impairment. The role of dietary supplement or restriction on AD-related cognitive impairment is related to multiple pathways. It is worth noting that the gut microbiome, as an important medium in the effect of dietary on the host, can influence cognitive function through the "microbial-gut-brain axis". The antioxidant and anti-inflammatory properties of some foods are beneficial for improving cognitive function. In this paper, relevant studies in recent years were analyzed to discuss the effects of certain single nutrients (vitamins, polyphenols, and long chain polyunsaturated fatty acids) and overall nutritional patterns (Mediterranean diet, dietary approaches to stop hypertension diet, Mediterranean-DASH intervention for neurodegenerative delay, and ketogenic diet) on cognitive function, so as to provide ideas and reference for the prevention and treatment of AD-related cognitive impairment. |
| first_indexed | 2024-03-08T00:02:01Z |
| format | Article |
| id | doaj.art-8486fc6b9d7a4a78886c79141efbd141 |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2024-03-08T00:02:01Z |
| publishDate | 2023-06-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-8486fc6b9d7a4a78886c79141efbd1412024-02-18T02:19:55ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-06-0143678879410.3969/j.issn.1674-8115.2023.06.0171674-8115（2023）06-0788-07Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's diseaseJIANG XintingHUANG GaozhongAlzheimer's disease (AD) is an age-related neurodegenerative disease with insidious onset and slow progression. The progression of AD from only brain pathological changes to clinically identifiable cognitive changes is affected by a variety of environmental factors inside and outside the organism and can last for decades. Cognitive impairment is an important clinical feature of AD that impairs the quality of life of the elderly in their later years, and the available drugs for the treatment of AD have failed to cure the disease, indicating the importance of early prevention of AD-related cognitive impairment. Most current research on the relationship between nutrition and AD takes nutritional intervention as a preventive method for AD-related cognitive impairment. The role of dietary supplement or restriction on AD-related cognitive impairment is related to multiple pathways. It is worth noting that the gut microbiome, as an important medium in the effect of dietary on the host, can influence cognitive function through the "microbial-gut-brain axis". The antioxidant and anti-inflammatory properties of some foods are beneficial for improving cognitive function. In this paper, relevant studies in recent years were analyzed to discuss the effects of certain single nutrients (vitamins, polyphenols, and long chain polyunsaturated fatty acids) and overall nutritional patterns (Mediterranean diet, dietary approaches to stop hypertension diet, Mediterranean-DASH intervention for neurodegenerative delay, and ketogenic diet) on cognitive function, so as to provide ideas and reference for the prevention and treatment of AD-related cognitive impairment.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-788.shtmlalzheimer's disease (ad)dietary patternnutritional compositioncognitive cognitive impairmentprevention |
| spellingShingle | JIANG Xinting HUANG Gaozhong Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease Shanghai Jiaotong Daxue xuebao. Yixue ban alzheimer's disease (ad) dietary pattern nutritional composition cognitive cognitive impairment prevention |
| title | Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease |
| title_full | Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease |
| title_fullStr | Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease |
| title_full_unstemmed | Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease |
| title_short | Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease |
| title_sort | research progress in the effect of nutritional intervention on cognitive impairment related to alzheimer s disease |
| topic | alzheimer's disease (ad) dietary pattern nutritional composition cognitive cognitive impairment prevention |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-788.shtml |
| work_keys_str_mv | AT jiangxinting researchprogressintheeffectofnutritionalinterventiononcognitiveimpairmentrelatedtoalzheimersdisease AT huanggaozhong researchprogressintheeffectofnutritionalinterventiononcognitiveimpairmentrelatedtoalzheimersdisease |