The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond
Heme oxygenase (HO-2) is an enzyme mainly involved in the physiologic turnover of heme and intracellular gas sensing, and it is very abundant in the brain, testes, kidneys and vessels. Since 1990, when HO-2 was discovered, the scientific community has underestimated the role of this protein in healt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1156333/full |
| _version_ | 1797844335471886336 |
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| author | Cesare Mancuso Cesare Mancuso |
| author_facet | Cesare Mancuso Cesare Mancuso |
| author_sort | Cesare Mancuso |
| collection | DOAJ |
| description | Heme oxygenase (HO-2) is an enzyme mainly involved in the physiologic turnover of heme and intracellular gas sensing, and it is very abundant in the brain, testes, kidneys and vessels. Since 1990, when HO-2 was discovered, the scientific community has underestimated the role of this protein in health and disease, as attested by the small amount of articles published and citations received. One of the reason that have contributed to the lack of interest in HO-2 was the difficulty in upregulating or inhibiting this enzyme. However, over the last 10 years, novel HO-2 agonists and antagonists have been synthesized, and the availability of these pharmacological tools should increase the appeal of HO-2 as drug target. In particular, these agonists and antagonists could help explain some controversial aspects, such as the neuroprotective versus neurotoxic roles of HO-2 in cerebrovascular diseases. Furthermore, the discovery of HO-2 genetic variants and their involvement in Parkinson’s disease, in particular in males, opens new avenues for pharmacogenetic studies in gender medicine. |
| first_indexed | 2024-04-09T17:20:36Z |
| format | Article |
| id | doaj.art-848a5df63a5c4b608bb3b047fed70c60 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T17:20:36Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-848a5df63a5c4b608bb3b047fed70c602023-04-19T04:22:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11563331156333The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyondCesare Mancuso0Cesare Mancuso1Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Healthcare Surveillance and Bioethics, Section of Pharmacology, Università Cattolica Del Sacro Cuore, Rome, ItalyHeme oxygenase (HO-2) is an enzyme mainly involved in the physiologic turnover of heme and intracellular gas sensing, and it is very abundant in the brain, testes, kidneys and vessels. Since 1990, when HO-2 was discovered, the scientific community has underestimated the role of this protein in health and disease, as attested by the small amount of articles published and citations received. One of the reason that have contributed to the lack of interest in HO-2 was the difficulty in upregulating or inhibiting this enzyme. However, over the last 10 years, novel HO-2 agonists and antagonists have been synthesized, and the availability of these pharmacological tools should increase the appeal of HO-2 as drug target. In particular, these agonists and antagonists could help explain some controversial aspects, such as the neuroprotective versus neurotoxic roles of HO-2 in cerebrovascular diseases. Furthermore, the discovery of HO-2 genetic variants and their involvement in Parkinson’s disease, in particular in males, opens new avenues for pharmacogenetic studies in gender medicine.https://www.frontiersin.org/articles/10.3389/fphar.2023.1156333/fullbilirubincarbon monoxidedrug research and developmentgender medicineneuroprotectionParkinson’s disease |
| spellingShingle | Cesare Mancuso Cesare Mancuso The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond Frontiers in Pharmacology bilirubin carbon monoxide drug research and development gender medicine neuroprotection Parkinson’s disease |
| title | The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond |
| title_full | The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond |
| title_fullStr | The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond |
| title_full_unstemmed | The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond |
| title_short | The impact of heme oxygenase-2 on pharmacological research: A bibliometric analysis and beyond |
| title_sort | impact of heme oxygenase 2 on pharmacological research a bibliometric analysis and beyond |
| topic | bilirubin carbon monoxide drug research and development gender medicine neuroprotection Parkinson’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1156333/full |
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