Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale
Background: Monosodium glutamate (MSG) or L-Glutamic acid is the sodium salt of glutamic acid is toxic to human and experimental animals. Liver and kidney may be susceptible to injury resulting from toxic substances. Ginger has immuno-modulatory, antitumorigenic, anti-inflammatory, anti-apoptotic,...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-04-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/219 |
| _version_ | 1797454771961987072 |
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| author | Snoor Jalal Mustafa Gulala Ibrahim Qader Shler Akram Faqe Mahmood |
| author_facet | Snoor Jalal Mustafa Gulala Ibrahim Qader Shler Akram Faqe Mahmood |
| author_sort | Snoor Jalal Mustafa |
| collection | DOAJ |
| description |
Background: Monosodium glutamate (MSG) or L-Glutamic acid is the sodium salt of glutamic acid is toxic to human and experimental animals. Liver and kidney may be susceptible to injury resulting from toxic substances. Ginger has immuno-modulatory, antitumorigenic, anti-inflammatory, anti-apoptotic, antihyperglycemic and anti-lipidemic actions.
Objective: This study has been carried out to evaluate the protective effects of aqueous extract of Zingiber Officinale in decreasing and ameliorating effects of Monosodium glutamate induced alteration in hepatic and renal tissues and their functions of rats.
Patients and Methods: Twenty four adult rats were divided into three equal groups and maintained under standard laboratory conditions. The ginger extract and the MSG were given orally once daily for 21 days. Group I Control: distilled water Group II: received MSG (4.0g/kg B.W) Group III: received 4.0g/kg B.W of MSG +100mg/Kg of ginger. After the last dose blood was collected.
Results: Monosodium Glutamate /L-Glutamate caused loss of normal histological architecture of liver and kidneys of rats of Group II with significant changes in biochemical parameters compared with control groups (P < 0.0001). Zingibar Officinale /Ginger is an excellent antioxidant substance that ameliorated and prevented the toxic effect of MSG in a group III treated with combination of MSG and Ginger histologically and functionally.
Conclusion: Zingibar Officinale (ginger) caused decrease the hepatotoxic and nephrotoxic effects resulted from oxidative damage induced by MSG because of their antioxidant effects.
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| first_indexed | 2024-03-09T15:41:52Z |
| format | Article |
| id | doaj.art-848bb2c0a9414ae0b1cf0a79795fecc0 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:41:52Z |
| publishDate | 2019-04-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-848bb2c0a9414ae0b1cf0a79795fecc02023-11-24T23:24:24ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-04-01112Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar OfficionaleSnoor Jalal MustafaGulala Ibrahim QaderShler Akram Faqe Mahmood Background: Monosodium glutamate (MSG) or L-Glutamic acid is the sodium salt of glutamic acid is toxic to human and experimental animals. Liver and kidney may be susceptible to injury resulting from toxic substances. Ginger has immuno-modulatory, antitumorigenic, anti-inflammatory, anti-apoptotic, antihyperglycemic and anti-lipidemic actions. Objective: This study has been carried out to evaluate the protective effects of aqueous extract of Zingiber Officinale in decreasing and ameliorating effects of Monosodium glutamate induced alteration in hepatic and renal tissues and their functions of rats. Patients and Methods: Twenty four adult rats were divided into three equal groups and maintained under standard laboratory conditions. The ginger extract and the MSG were given orally once daily for 21 days. Group I Control: distilled water Group II: received MSG (4.0g/kg B.W) Group III: received 4.0g/kg B.W of MSG +100mg/Kg of ginger. After the last dose blood was collected. Results: Monosodium Glutamate /L-Glutamate caused loss of normal histological architecture of liver and kidneys of rats of Group II with significant changes in biochemical parameters compared with control groups (P < 0.0001). Zingibar Officinale /Ginger is an excellent antioxidant substance that ameliorated and prevented the toxic effect of MSG in a group III treated with combination of MSG and Ginger histologically and functionally. Conclusion: Zingibar Officinale (ginger) caused decrease the hepatotoxic and nephrotoxic effects resulted from oxidative damage induced by MSG because of their antioxidant effects. http://djm.uodiyala.edu.iq/index.php/djm/article/view/219Monosodium glutamate, ginger, antioxidant, liver, kidney |
| spellingShingle | Snoor Jalal Mustafa Gulala Ibrahim Qader Shler Akram Faqe Mahmood Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale Diyala Journal of Medicine Monosodium glutamate, ginger, antioxidant, liver, kidney |
| title | Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale |
| title_full | Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale |
| title_fullStr | Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale |
| title_full_unstemmed | Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale |
| title_short | Effect of L-Glutamic acid on histology and functions of Liver and kidney of Rats and Protective Role of Zingibar Officionale |
| title_sort | effect of l glutamic acid on histology and functions of liver and kidney of rats and protective role of zingibar officionale |
| topic | Monosodium glutamate, ginger, antioxidant, liver, kidney |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/219 |
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