Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury
Paraparesis and paraplegia are common conditions in dogs, most often caused by a disc herniation in the thoracolumbar spinal segments (T3-L3), which is a neurological emergency. Surgical decompression should be performed as soon as possible when spinal compression is revealed by myelography, compute...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fvets.2019.00383/full |
| _version_ | 1818023892473610240 |
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| author | Fernando Swiech Bach Carmen Lucia Kuniyoshi Rebelatto Leticia Fracaro Alexandra Cristina Senegaglia Felipe Yukio Ishikawa Fragoso Debora Regina Daga Paulo Roberto Slud Brofman Claudia Turra Pimpão Jair Rodini Engracia Filho Fabiano Montiani-Ferreira José Ademar Villanova |
| author_facet | Fernando Swiech Bach Carmen Lucia Kuniyoshi Rebelatto Leticia Fracaro Alexandra Cristina Senegaglia Felipe Yukio Ishikawa Fragoso Debora Regina Daga Paulo Roberto Slud Brofman Claudia Turra Pimpão Jair Rodini Engracia Filho Fabiano Montiani-Ferreira José Ademar Villanova |
| author_sort | Fernando Swiech Bach |
| collection | DOAJ |
| description | Paraparesis and paraplegia are common conditions in dogs, most often caused by a disc herniation in the thoracolumbar spinal segments (T3-L3), which is a neurological emergency. Surgical decompression should be performed as soon as possible when spinal compression is revealed by myelography, computed tomography, or magnetic resonance imaging. Mesenchymal stem-cell therapy is a promising adjunct treatment for spinal cord injury. This study sought to compare the effects of surgical decompression alone and combined with an allogeneic transplantation of canine adipose tissue-derived mesenchymal stem cells (cAd-MSCs) in the treatment of dogs with acute paraplegia. Twenty-two adult dogs of different breeds with acute paraplegia resulting from a Hansen type I disc herniation in the thoracolumbar region (T3-L3) were evaluated using computed tomography. All dogs had grade IV or V lesions and underwent surgery within 7 days after symptom onset. They were randomly assigned into two groups, 11 dogs in each. The dogs in Group I underwent hemilaminectomy, and those in Group II underwent hemilaminectomy and cAd-MSC epidural transplantation. In both groups, all dogs with grade IV lesions recovered locomotion. The median locomotion recovery period was 7 days for Group II and 21 days for Group I, and this difference was statistically significant (p < 0.05). Moreover, the median length of hospitalization after the surgery was statistically different between the two groups (Group I, 4 days; Group II, 3 days; p < 0.05). There were no statistically significant between-group differences regarding the number of animals with grade IV or V lesions that recovered locomotion and nociception. In conclusion, compared with surgical decompression alone, the use of epidural cAd-MSC transplantation with surgical decompression may contribute to faster locomotor recovery in dogs with acute paraplegia and reduce the length of post-surgery hospitalization. |
| first_indexed | 2024-12-10T03:51:32Z |
| format | Article |
| id | doaj.art-848cfa456a72470d863ab371143e5f5f |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-10T03:51:32Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-848cfa456a72470d863ab371143e5f5f2022-12-22T02:03:14ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692019-11-01610.3389/fvets.2019.00383450675Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord InjuryFernando Swiech Bach0Carmen Lucia Kuniyoshi Rebelatto1Leticia Fracaro2Alexandra Cristina Senegaglia3Felipe Yukio Ishikawa Fragoso4Debora Regina Daga5Paulo Roberto Slud Brofman6Claudia Turra Pimpão7Jair Rodini Engracia Filho8Fabiano Montiani-Ferreira9José Ademar Villanova10Department of Neurology, Clinivet Veterinary Hospital, Curitiba, BrazilNucleus of Cellular Technology, Pontifical Catholic University of Paraná, Curitiba, BrazilNucleus of Cellular Technology, Pontifical Catholic University of Paraná, Curitiba, BrazilNucleus of Cellular Technology, Pontifical Catholic University of Paraná, Curitiba, BrazilNucleus of Cellular Technology, Pontifical Catholic University of Paraná, Curitiba, BrazilNucleus of Cellular Technology, Pontifical Catholic University of Paraná, Curitiba, BrazilNucleus of Cellular Technology, Pontifical Catholic University of Paraná, Curitiba, BrazilPostgraduate Program in Animal Science, Pontifical Catholic University of Paraná, Curitiba, BrazilPostgraduate Program in Animal Science, Pontifical Catholic University of Paraná, Curitiba, BrazilGraduate Program in Veterinary Science, Universidade Federal Do Paraná, Curitiba, BrazilPostgraduate Program in Animal Science, Pontifical Catholic University of Paraná, Curitiba, BrazilParaparesis and paraplegia are common conditions in dogs, most often caused by a disc herniation in the thoracolumbar spinal segments (T3-L3), which is a neurological emergency. Surgical decompression should be performed as soon as possible when spinal compression is revealed by myelography, computed tomography, or magnetic resonance imaging. Mesenchymal stem-cell therapy is a promising adjunct treatment for spinal cord injury. This study sought to compare the effects of surgical decompression alone and combined with an allogeneic transplantation of canine adipose tissue-derived mesenchymal stem cells (cAd-MSCs) in the treatment of dogs with acute paraplegia. Twenty-two adult dogs of different breeds with acute paraplegia resulting from a Hansen type I disc herniation in the thoracolumbar region (T3-L3) were evaluated using computed tomography. All dogs had grade IV or V lesions and underwent surgery within 7 days after symptom onset. They were randomly assigned into two groups, 11 dogs in each. The dogs in Group I underwent hemilaminectomy, and those in Group II underwent hemilaminectomy and cAd-MSC epidural transplantation. In both groups, all dogs with grade IV lesions recovered locomotion. The median locomotion recovery period was 7 days for Group II and 21 days for Group I, and this difference was statistically significant (p < 0.05). Moreover, the median length of hospitalization after the surgery was statistically different between the two groups (Group I, 4 days; Group II, 3 days; p < 0.05). There were no statistically significant between-group differences regarding the number of animals with grade IV or V lesions that recovered locomotion and nociception. In conclusion, compared with surgical decompression alone, the use of epidural cAd-MSC transplantation with surgical decompression may contribute to faster locomotor recovery in dogs with acute paraplegia and reduce the length of post-surgery hospitalization.https://www.frontiersin.org/article/10.3389/fvets.2019.00383/fulldogsparaplegiaspinal cordneurosurgerycell therapystem cells |
| spellingShingle | Fernando Swiech Bach Carmen Lucia Kuniyoshi Rebelatto Leticia Fracaro Alexandra Cristina Senegaglia Felipe Yukio Ishikawa Fragoso Debora Regina Daga Paulo Roberto Slud Brofman Claudia Turra Pimpão Jair Rodini Engracia Filho Fabiano Montiani-Ferreira José Ademar Villanova Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury Frontiers in Veterinary Science dogs paraplegia spinal cord neurosurgery cell therapy stem cells |
| title | Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury |
| title_full | Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury |
| title_fullStr | Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury |
| title_full_unstemmed | Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury |
| title_short | Comparison of the Efficacy of Surgical Decompression Alone and Combined With Canine Adipose Tissue-Derived Stem Cell Transplantation in Dogs With Acute Thoracolumbar Disk Disease and Spinal Cord Injury |
| title_sort | comparison of the efficacy of surgical decompression alone and combined with canine adipose tissue derived stem cell transplantation in dogs with acute thoracolumbar disk disease and spinal cord injury |
| topic | dogs paraplegia spinal cord neurosurgery cell therapy stem cells |
| url | https://www.frontiersin.org/article/10.3389/fvets.2019.00383/full |
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