Disulfiram in glioma: Literature review of drug repurposing
Gliomas are the most common malignant brain tumors. High-grade gliomas, represented by glioblastoma multiforme (GBM), have a poor prognosis and are prone to recurrence. The standard treatment strategy is tumor removal combined with radiotherapy and chemotherapy, such as temozolomide (TMZ). However,...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.933655/full |
| _version_ | 1828148774229245952 |
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| author | Shiyu Zhong Shengyu Liu Xin Shi Xin Shi Xudong Zhang Kunhang Li Guojun Liu Lishuai Li Shanwei Tao Bowen Zheng Weichen Sheng Ziyin Ye Qichen Xing Qingqing Zhai Lijie Ren Ying Wu Yijun Bao |
| author_facet | Shiyu Zhong Shengyu Liu Xin Shi Xin Shi Xudong Zhang Kunhang Li Guojun Liu Lishuai Li Shanwei Tao Bowen Zheng Weichen Sheng Ziyin Ye Qichen Xing Qingqing Zhai Lijie Ren Ying Wu Yijun Bao |
| author_sort | Shiyu Zhong |
| collection | DOAJ |
| description | Gliomas are the most common malignant brain tumors. High-grade gliomas, represented by glioblastoma multiforme (GBM), have a poor prognosis and are prone to recurrence. The standard treatment strategy is tumor removal combined with radiotherapy and chemotherapy, such as temozolomide (TMZ). However, even after conventional treatment, they still have a high recurrence rate, resulting in an increasing demand for effective anti-glioma drugs. Drug repurposing is a method of reusing drugs that have already been widely approved for new indication. It has the advantages of reduced research cost, safety, and increased efficiency. Disulfiram (DSF), originally approved for alcohol dependence, has been repurposed for adjuvant chemotherapy in glioma. This article reviews the drug repurposing method and the progress of research on disulfiram reuse for glioma treatment. |
| first_indexed | 2024-04-11T21:20:29Z |
| format | Article |
| id | doaj.art-848e79fa0cd94c14a1fb748df2fc4ada |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T21:20:29Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-848e79fa0cd94c14a1fb748df2fc4ada2022-12-22T04:02:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.933655933655Disulfiram in glioma: Literature review of drug repurposingShiyu Zhong0 Shengyu Liu1 Xin Shi2 Xin Shi3Xudong Zhang4Kunhang Li5Guojun Liu6Lishuai Li7Shanwei Tao8Bowen Zheng9Weichen Sheng10Ziyin Ye11Qichen Xing12Qingqing Zhai13Lijie Ren14Ying Wu15Yijun Bao16Department of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaSchool of Maths and Information Science, Shandong Technology and Business University, Yantai, ChinaBusiness School, All Saints Campus, Manchester Metropolitan University, Manchester, United KingdomDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaLuoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaSchool of Management, Shanghai University, Shanghai, ChinaNeurology Department of Shenzhen Second People’s Hospital/ First Affiliated Hospital of Shenzhen, University Health Science Center, Shenzhen, ChinaDepartment of General Practice, The First Hospital, China Medical University, Shenyang, ChinaDepartment of Neurosurgery, The Fourth Hospital of China Medical University, Huanggu, Shenyang, ChinaGliomas are the most common malignant brain tumors. High-grade gliomas, represented by glioblastoma multiforme (GBM), have a poor prognosis and are prone to recurrence. The standard treatment strategy is tumor removal combined with radiotherapy and chemotherapy, such as temozolomide (TMZ). However, even after conventional treatment, they still have a high recurrence rate, resulting in an increasing demand for effective anti-glioma drugs. Drug repurposing is a method of reusing drugs that have already been widely approved for new indication. It has the advantages of reduced research cost, safety, and increased efficiency. Disulfiram (DSF), originally approved for alcohol dependence, has been repurposed for adjuvant chemotherapy in glioma. This article reviews the drug repurposing method and the progress of research on disulfiram reuse for glioma treatment.https://www.frontiersin.org/articles/10.3389/fphar.2022.933655/fullgliomasglioblastoma multiformedisulfiramdrug repurposingtemozolomide |
| spellingShingle | Shiyu Zhong Shengyu Liu Xin Shi Xin Shi Xudong Zhang Kunhang Li Guojun Liu Lishuai Li Shanwei Tao Bowen Zheng Weichen Sheng Ziyin Ye Qichen Xing Qingqing Zhai Lijie Ren Ying Wu Yijun Bao Disulfiram in glioma: Literature review of drug repurposing Frontiers in Pharmacology gliomas glioblastoma multiforme disulfiram drug repurposing temozolomide |
| title | Disulfiram in glioma: Literature review of drug repurposing |
| title_full | Disulfiram in glioma: Literature review of drug repurposing |
| title_fullStr | Disulfiram in glioma: Literature review of drug repurposing |
| title_full_unstemmed | Disulfiram in glioma: Literature review of drug repurposing |
| title_short | Disulfiram in glioma: Literature review of drug repurposing |
| title_sort | disulfiram in glioma literature review of drug repurposing |
| topic | gliomas glioblastoma multiforme disulfiram drug repurposing temozolomide |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.933655/full |
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