Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study
Dietary fatty acids play a critical role in modulation of airway inflammation in asthma. This study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammato...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2014-10-01
|
| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/436 |
| _version_ | 1811268055529947136 |
|---|---|
| author | Fatemeh Haidari Majid Mohammadshahi Seyed Hamid Borsi Mohammad-Hossein Haghighizadeh Shokouh Malgard |
| author_facet | Fatemeh Haidari Majid Mohammadshahi Seyed Hamid Borsi Mohammad-Hossein Haghighizadeh Shokouh Malgard |
| author_sort | Fatemeh Haidari |
| collection | DOAJ |
| description | Dietary fatty acids play a critical role in modulation of airway inflammation in asthma. This study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammatory markers and dietary fatty acids. In this case-control study, 47 asthmatic patients (26 males and 21 females) were compared with 47 controls (24 males and 23 females). Blood samples were taken from case and control groups and tumor necrosis factor-α (TNF-α), high sensitive C-reactive protein (hs-CRP), leptin and adiponectin were determined. Dietary intakes were assessed by semi-quantitative food frequency questionnaire (FFQ). Dietary intakes of omega-3 fatty acids were significantly lower in asthmatic patients compared to controls (p<0.05). Serum concentrations of TNF-α, hs-CRP and leptin were significantly higher in asthmatic patients. There was a significant negative relationship between adiponectin levels and saturated fatty acid intakes in both groups, but the relationship between adiponectin and mono-unsaturated fatty acid intakes was positive and significant only in asthmatic group. No significant correlation between other inflammatory factors and dietary intakes was found in this study. Higher intake of omega-3 and lower levels of inflammatory factors in the healthy control group compared to asthmatic group may explain the protective role of essential fatty acids in asthma. Further studies with larger sample size are needed in this regard. |
| first_indexed | 2024-04-12T21:13:51Z |
| format | Article |
| id | doaj.art-848fb956a1ae4c73ae6ac6d8fe8d2206 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-04-12T21:13:51Z |
| publishDate | 2014-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-848fb956a1ae4c73ae6ac6d8fe8d22062022-12-22T03:16:30ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492014-10-01135401Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control StudyFatemeh Haidari0Majid Mohammadshahi1Seyed Hamid Borsi2Mohammad-Hossein Haghighizadeh3Shokouh Malgard4Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Nutritional Science, Arvand International Division of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Dietary fatty acids play a critical role in modulation of airway inflammation in asthma. This study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammatory markers and dietary fatty acids. In this case-control study, 47 asthmatic patients (26 males and 21 females) were compared with 47 controls (24 males and 23 females). Blood samples were taken from case and control groups and tumor necrosis factor-α (TNF-α), high sensitive C-reactive protein (hs-CRP), leptin and adiponectin were determined. Dietary intakes were assessed by semi-quantitative food frequency questionnaire (FFQ). Dietary intakes of omega-3 fatty acids were significantly lower in asthmatic patients compared to controls (p<0.05). Serum concentrations of TNF-α, hs-CRP and leptin were significantly higher in asthmatic patients. There was a significant negative relationship between adiponectin levels and saturated fatty acid intakes in both groups, but the relationship between adiponectin and mono-unsaturated fatty acid intakes was positive and significant only in asthmatic group. No significant correlation between other inflammatory factors and dietary intakes was found in this study. Higher intake of omega-3 and lower levels of inflammatory factors in the healthy control group compared to asthmatic group may explain the protective role of essential fatty acids in asthma. Further studies with larger sample size are needed in this regard.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/436AdiponectinAsthmaFatty acidhs-CRPLeptinTNF-α |
| spellingShingle | Fatemeh Haidari Majid Mohammadshahi Seyed Hamid Borsi Mohammad-Hossein Haghighizadeh Shokouh Malgard Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study Iranian Journal of Allergy, Asthma and Immunology Adiponectin Asthma Fatty acid hs-CRP Leptin TNF-α |
| title | Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study |
| title_full | Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study |
| title_fullStr | Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study |
| title_full_unstemmed | Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study |
| title_short | Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study |
| title_sort | comparison of essential fatty acid intakes and serum levels of inflammatory factors between asthmatic and healthy adults a case control study |
| topic | Adiponectin Asthma Fatty acid hs-CRP Leptin TNF-α |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/436 |
| work_keys_str_mv | AT fatemehhaidari comparisonofessentialfattyacidintakesandserumlevelsofinflammatoryfactorsbetweenasthmaticandhealthyadultsacasecontrolstudy AT majidmohammadshahi comparisonofessentialfattyacidintakesandserumlevelsofinflammatoryfactorsbetweenasthmaticandhealthyadultsacasecontrolstudy AT seyedhamidborsi comparisonofessentialfattyacidintakesandserumlevelsofinflammatoryfactorsbetweenasthmaticandhealthyadultsacasecontrolstudy AT mohammadhosseinhaghighizadeh comparisonofessentialfattyacidintakesandserumlevelsofinflammatoryfactorsbetweenasthmaticandhealthyadultsacasecontrolstudy AT shokouhmalgard comparisonofessentialfattyacidintakesandserumlevelsofinflammatoryfactorsbetweenasthmaticandhealthyadultsacasecontrolstudy |