Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing
Incorporation of curcumin (Cur) into a hydrogel system is an interesting approach to treat full-thickness skin wounds because Cur can potentiate healing by affecting different stages of the wound healing. Due to its hydrophobicity, Cur solubilization is a great challenge. Thus, Cur solubilization by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Materials & Design |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127519307518 |
| _version_ | 1819076153574424576 |
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| author | Anha Afrin Shefa Tamanna Sultana Myeong Ki Park Sun Young Lee Jae-Gyoung Gwon Byong-Taek Lee |
| author_facet | Anha Afrin Shefa Tamanna Sultana Myeong Ki Park Sun Young Lee Jae-Gyoung Gwon Byong-Taek Lee |
| author_sort | Anha Afrin Shefa |
| collection | DOAJ |
| description | Incorporation of curcumin (Cur) into a hydrogel system is an interesting approach to treat full-thickness skin wounds because Cur can potentiate healing by affecting different stages of the wound healing. Due to its hydrophobicity, Cur solubilization is a great challenge. Thus, Cur solubilization by pluronic F-127, gelation capacity of polyvinyl alcohol (PVA) and porosity enhancement by TEMPO-oxidized cellulose nanofiber (TOCN) can inaugurate a biocompatible and biodegradable hydrogel system for Cur delivery. In this study, a Cur incorporated physically crosslinked TOCN-PVA-Cur hydrogel was prepared by a freeze-thaw process, which released Cur to accelerate wound healing. The viscosity of the hydrogel was increased by increasing the PVA concentration. In vitro studies revealed that, L929 fibroblast cells internalized curcumin within 4 h of incubation. After the application of the TOCN-PVA-Cur into rat full-thickness skin wounds, the percentage of wound closures was increased compared to that in the control group. Distinct neoepidermise and granulation tissue formed in hydrogel treated groups and collagen fibers accumulated near defect areas at the two weeks after treatment. These results showed show that the delivery of curcumin by TOCN-PVA-Cur hydrogel can be an effective method for promoting natural wound healing processes. Keywords: Wound healing, Hydrogel, Curcumin, Oxidized cellulose nanofiber, Polyvinyl alcohol |
| first_indexed | 2024-12-21T18:36:47Z |
| format | Article |
| id | doaj.art-8491f2ae93704e858a02d8d3c2ed547b |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-21T18:36:47Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-8491f2ae93704e858a02d8d3c2ed547b2022-12-21T18:54:07ZengElsevierMaterials & Design0264-12752020-01-01186Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healingAnha Afrin Shefa0Tamanna Sultana1Myeong Ki Park2Sun Young Lee3Jae-Gyoung Gwon4Byong-Taek Lee5Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan 31151, Republic of KoreaDepartment of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan 31151, Republic of KoreaInstitute of Tissue Regeneration, College of Medicine, Soonchunhyang University 366-1, Cheonan 31151, Republic of KoreaDivision of Environmental Material Engineering, Department of Forest Products, Korea Forest Research Institute, Republic of KoreaDivision of Environmental Material Engineering, Department of Forest Products, Korea Forest Research Institute, Republic of KoreaDepartment of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan 31151, Republic of Korea; Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University 366-1, Cheonan 31151, Republic of Korea; Corresponding author at: Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan 31151, Republic of Korea.Incorporation of curcumin (Cur) into a hydrogel system is an interesting approach to treat full-thickness skin wounds because Cur can potentiate healing by affecting different stages of the wound healing. Due to its hydrophobicity, Cur solubilization is a great challenge. Thus, Cur solubilization by pluronic F-127, gelation capacity of polyvinyl alcohol (PVA) and porosity enhancement by TEMPO-oxidized cellulose nanofiber (TOCN) can inaugurate a biocompatible and biodegradable hydrogel system for Cur delivery. In this study, a Cur incorporated physically crosslinked TOCN-PVA-Cur hydrogel was prepared by a freeze-thaw process, which released Cur to accelerate wound healing. The viscosity of the hydrogel was increased by increasing the PVA concentration. In vitro studies revealed that, L929 fibroblast cells internalized curcumin within 4 h of incubation. After the application of the TOCN-PVA-Cur into rat full-thickness skin wounds, the percentage of wound closures was increased compared to that in the control group. Distinct neoepidermise and granulation tissue formed in hydrogel treated groups and collagen fibers accumulated near defect areas at the two weeks after treatment. These results showed show that the delivery of curcumin by TOCN-PVA-Cur hydrogel can be an effective method for promoting natural wound healing processes. Keywords: Wound healing, Hydrogel, Curcumin, Oxidized cellulose nanofiber, Polyvinyl alcoholhttp://www.sciencedirect.com/science/article/pii/S0264127519307518 |
| spellingShingle | Anha Afrin Shefa Tamanna Sultana Myeong Ki Park Sun Young Lee Jae-Gyoung Gwon Byong-Taek Lee Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing Materials & Design |
| title | Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing |
| title_full | Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing |
| title_fullStr | Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing |
| title_full_unstemmed | Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing |
| title_short | Curcumin incorporation into an oxidized cellulose nanofiber-polyvinyl alcohol hydrogel system promotes wound healing |
| title_sort | curcumin incorporation into an oxidized cellulose nanofiber polyvinyl alcohol hydrogel system promotes wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127519307518 |
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